SHANK3 and TFIP11

Number of citations of the paper that reports this interaction (PubMedID 21653829)
98

Data Source:
BioGRID (two hybrid)

		SHANK3	TFIP11
Description		SH3 and multiple ankyrin repeat domains 3	tuftelin interacting protein 11
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Postsynaptic Density Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Neuron Projection Dendritic Spine Neuron Spine Postsynaptic Membrane Ciliary Membrane	Chromosome, Telomeric Region Nucleoplasm Spliceosomal Complex Nucleolus Cytoplasm Nuclear Speck Extracellular Matrix U2-type Post-mRNA Release Spliceosomal Complex Catalytic Step 2 Spliceosome
	Molecular Function	Actin Binding Protein Binding Protein C-terminus Binding Zinc Ion Binding SH3 Domain Binding Synaptic Receptor Adaptor Activity Ionotropic Glutamate Receptor Binding Protein Self-association Scaffold Protein Binding	Nucleic Acid Binding Protein Binding
	Biological Process	MAPK Cascade Synapse Assembly Learning Memory Striatal Medium Spiny Neuron Differentiation Adult Behavior Negative Regulation Of Actin Filament Bundle Assembly Social Behavior Vocal Learning Negative Regulation Of Cell Volume Positive Regulation Of Long-term Neuronal Synaptic Plasticity Brain Morphogenesis Positive Regulation Of Synapse Structural Plasticity Positive Regulation Of Synaptic Transmission, Glutamatergic Dendritic Spine Morphogenesis Positive Regulation Of Dendritic Spine Development Regulation Of Dendritic Spine Morphogenesis Vocalization Behavior Postsynaptic Density Assembly AMPA Glutamate Receptor Clustering NMDA Glutamate Receptor Clustering Guanylate Kinase-associated Protein Clustering Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Long-term Synaptic Potentiation Positive Regulation Of Glutamate Receptor Signaling Pathway Regulation Of Long-term Synaptic Depression Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of AMPA Receptor Activity	Spliceosomal Complex Disassembly MRNA Splicing, Via Spliceosome RNA Processing Biomineral Tissue Development Negative Regulation Of Protein-containing Complex Assembly Protection From Non-homologous End Joining At Telomere Negative Regulation Of Protein Binding Negative Regulation Of DNA Ligase Activity Negative Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways			mRNA Splicing - Major Pathway
Drugs
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Blood protein levels ( 30072576) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Extremely high intelligence ( 29520040) Fibrinogen ( 23969696) Fibrinogen levels ( 28107422 26561523) Intelligence (MTAG) ( 29326435) Mean platelet volume ( 32888494) Memory dysfunction in frontotemporal lobe dementia ( 29724592) Platelet count ( 32888494)
Interacting Genes		156 interacting genes: ABCC2 ABI1 ABI2 ACE2 ACTN2 ADGRL1 AGAP7P ALDOA ANKRD35 APP ARHGAP44 ARPC2 ARPC5L ATN1 BAIAP2 C1QBP CA10 CALCOCO1 CAMK2B CCT3 CENPJ CEP72 CIBAR1 CLTA CLU CNKSR2 COPS5 COPS6 COQ5 CRELD1 CRKL CSNK1D CSNK2B CTTN CYP51A1 CYTIP DBNL DCTN2 DDB1 DLGAP1 DLGAP2 DLGAP3 DLGAP4 DNAJA3 DNM2 EFEMP1 EFEMP2 EID1 ELAVL1 ERI3 FAM13A FBXO7 FKBP8 FRS3 FRYL GAPDH GOT1 GPR162 GPS1 GRB2 GRN HAGH HECW1 HGS HNRNPK HOMER3 ICA1 IGSF9 ITGBL1 ITSN1 JAG2 KHDRBS1 KIAA0232 LINGO1 LRRC73 LTBP3 LTBP4 LZTS2 LZTS3 MAPK1 MBIP MBOAT7 MCRS1 MDH2 MEGF10 MEGF11 MEGF6 MIPOL1 MRM3 MT-CO2 MT-ND6 MYO5B N4BP3 NCK1 NCKIPSD NEFL NGRN NOTCH1 NOTCH2 NOTCH2NLA NOTCH3 NR1D1 NRBF2 PAX6 PDHB PFKL PHF12 PHLDB1 PLEKHA4 PPHLN1 PPP1CC PPP1R13L PPP1R9B PPP2R3B PRMT2 QSOX1 RBM5 RPL3 RPS6KA1 RTN3 RUNDC3A SCYL3 SETD2 SH3GL2 SH3GL3 SHANK1 SHARPIN SIPA1 SLC48A1 SNRPN SORBS2 SORBS3 SPAG5 SPTAN1 SRSF9 STK32C SYNGAP1 SYT5 TCF25 TDRD7 TFIP11 THRAP3 TMEM14C TNIP2 TRAF3 TRIM27 TRIM9 TRIP10 TSG101 TUBA1C UCHL1 USP8 VIM VPS18 WWP1 ZCCHC2	234 interacting genes: AARD ABI2 ABLIM3 AIMP2 ANKRD11 AP1M1 ARHGEF9 ARMC7 ARMCX1 ARNT2 ATP5PO ATPAF2 AXIN1 BAZ2B BCL6 BHLHA9 BMF BRD1 BYSL C1orf109 C2CD6 CARD9 CAVIN3 CBX8 CCDC102B CCDC116 CCDC120 CCDC121 CCDC13 CCDC146 CCDC187 CCDC196 CCDC42 CCDC57 CCDC6 CCDC68 CCDC96 CCHCR1 CCND3 CCNG1 CCNL1 CCP110 CDKN1A CDR2L CENPU CEP57 CEP57L1 CEP95 CFAP206 COQ8A COX5B CT55 CWF19L2 DAXX DDX25 DES DGCR6 DISC1 DPPA3 DTNB EAF2 EIF3A EIF3D ENOX2 EPM2AIP1 EXOC3L1 EXOC8 EXOSC5 FAM13C FAM156A FAM161A FAM161B FAM50B FAM81A FAM90A1 FANCG FGA GADD45GIP1 GAS2L2 GCC1 GCFC2 GEM GFAP GNG4 GOLGA1 GOLGA2 GPS2 GRAP2 GSE1 HAUS1 HDAC4 HIP1R HMG20B HOOK1 HSF2BP IKBIP IL16 IMP3 JRK KANK2 KANSL1 KAT5 KDM1A KIF3C KIF9 KIFC3 KIZ KRT1 KRT20 KRT6A KRT6B KRT6C KRT8 LATS1 LCA5 LCA5L LENG1 LIN37 LMNB2 LMO1 LMO2 LMO4 LSM3 LSP1P3 LYSMD1 MAB21L2 MCM7 MDM2 METTL17 MFAP1 MKRN3 MRPL11 MTFR2 MXD3 MYO15B MYOM1 NDC80 NDE1 NDN NEK6 NFKBID NFU1 NSMF NUP88 ODAD3 OIP5 PBX3 PBX4 PCM1 PDE4DIP PHF1 PIBF1 PICK1 PKN3 PLK4 POLL POLR1C POM121 PPFIA3 PPP1R16A PPP1R16B PPP1R18 PRPF31 PSMA4 PSMC5 PSTPIP1 PTCD1 RCOR3 RHNO1 RIN1 RNF6 RRP7A RUNX1T1 RXRB S100P SAP30BP SCNM1 SFR1 SGF29 SH2D4A SH3GLB1 SHANK3 SMARCB1 SMARCE1 SNAPIN SNRPB SNW1 SNX20 SNX32 SOGA1 SPG21 SSX2IP STRA8 STRN SYCE1 TBC1D30 TBRG4 TCAF1 TDP2 TFPT THAP7 THAP8 TNNT1 TP53 TRAF3IP3 TRAPPC4 TRIM45 TRIML2 TSC1 TSG101 TSGA10IP TSHZ2 TSHZ3 TSPYL4 TUFT1 TXLNA TXN2 UBTFL1 USP2 USP6 USP7 VPS37C VPS39 WAC WASHC3 ZC2HC1C ZFYVE26 ZGPAT ZMAT2 ZNF417 ZNF572 ZNF587 ZNF777 ZSCAN12
Entrez ID		85358	24144
HPRD ID		18979	11628
Ensembl ID		ENSG00000251322	ENSG00000100109
Uniprot IDs			A0A024R1I7 Q9UBB9
PDB IDs
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?