CST7 and CTSL

Number of citations of the paper that reports this interaction (PubMedID 9733783)
29

Data Source:
HPRD (in vitro)

		CST7	CTSL
Description		cystatin F	cathepsin L
Image
GO Annotations	Cellular Component	Extracellular Space Lysosome Endosome Late Endosome Multivesicular Body Endoplasmic Reticulum Golgi Apparatus Cytoplasmic Vesicle	Extracellular Region Extracellular Space Nucleus Lysosome Multivesicular Body Golgi Apparatus Plasma Membrane Apical Plasma Membrane Endolysosome Lumen Chromaffin Granule Lysosomal Lumen Intracellular Membrane-bounded Organelle Collagen-containing Extracellular Matrix Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Protein Homodimerization Activity	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Cysteine-type Peptidase Activity Histone Binding Proteoglycan Binding Serpin Family Protein Binding
	Biological Process	Immune Response Negative Regulation Of Peptidase Activity Positive Regulation Of Myelination Inhibition Of Cysteine-type Endopeptidase Activity Negative Regulation Of Microglial Cell Activation	Adaptive Immune Response Proteolysis Immune Response Protein Autoprocessing Fusion Of Virus Membrane With Host Plasma Membrane Receptor-mediated Endocytosis Of Virus By Host Cell Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Collagen Catabolic Process Zymogen Activation Enkephalin Processing Fusion Of Virus Membrane With Host Endosome Membrane CD4-positive, Alpha-beta T Cell Lineage Commitment Viral Entry Into Host Cell Antigen Processing And Presentation Of Peptide Antigen Proteolysis Involved In Cellular Protein Catabolic Process Elastin Catabolic Process Macrophage Apoptotic Process Cellular Response To Thyroid Hormone Stimulus
Pathways			Endosomal/Vacuolar pathway Collagen degradation Degradation of the extracellular matrix Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Attachment and Entry Attachment and Entry Attachment and Entry
Drugs			L-cysteic acid Felbinac Fostamatinib
Diseases
GWAS		Alcohol consumption (drinks per week) ( 30643258) Blood protein levels ( 30072576 29875488 28240269) LDL cholesterol levels in HIV infection ( 33109212)
Interacting Genes		3 interacting genes: BMP1 CTSB CTSL	28 interacting genes: ARSA BAG6 BTN3A3 CD7 CD74 COL18A1 CST3 CST7 CSTA CSTB CTSC CUX1 CXCL8 EED GCG GEM IGFBP3 KNG1 MCPH1 PLAU PPP1CC RELB RXRA SERPINB13 SERPINB3 SGTA SLPI TG
Entrez ID		8530	1514
HPRD ID		04458	00293
Ensembl ID		ENSG00000077984	ENSG00000135047
Uniprot IDs		O76096	A0A024R276 P07711 Q9HBQ7
PDB IDs		2CH9	1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE 3OF8 3OF9 4AXL 4AXM 5F02 5I4H 5MAE 5MAJ 5MQY 6EZP 6EZX 6F06 6JD0 6JD8
Enriched GO Terms of Interacting Partners?
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