ZNRF1 and UBE2V2

Number of citations of the paper that reports this interaction (PubMedID 19549727)
74

Data Source:
BioGRID (two hybrid)

		ZNRF1	UBE2V2
Description		zinc and ring finger 1	ubiquitin conjugating enzyme E2 V2
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GO Annotations	Cellular Component	Lysosome Endosome Cytosol Membrane Synaptic Vesicle Membrane	Nucleus Nucleoplasm Cytoplasm UBC13-MMS2 Complex Extracellular Exosome
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity	Protein Binding
	Biological Process	Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination	Protein Polyubiquitination DNA Double-strand Break Processing Regulation Of DNA Repair Postreplication Repair Positive Regulation Of Neuron Projection Development Protein Ubiquitination Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Error-free Postreplication DNA Repair Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of DNA Repair Positive Regulation Of Synapse Assembly Protein K63-linked Ubiquitination
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Formation of Incision Complex in GG-NER G2/M DNA damage checkpoint E3 ubiquitin ligases ubiquitinate target proteins Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Crohn's disease (time to surgery) ( 23665963)	Height ( 31562340)
Interacting Genes		15 interacting genes: ATP1A1 CDC34 UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2E3 UBE2N UBE2V1 UBE2V2 UBE2W UBXN7	31 interacting genes: BCL10 DZIP3 EGFR HLTF IGSF21 LRIF1 MALT1 MKRN3 MOB4 MUL1 OTUB1 RC3H1 RC3H2 RFFL RNF144A RNF2 RNF8 SHPRH SIAH1 SIAH2 STUB1 SUV39H2 TP53 TRAF2 TRIM5 TRIM54 TRIM63 UBC UBE2N XIAP ZNRF1
Entrez ID		84937	7336
HPRD ID		15893	04300
Ensembl ID		ENSG00000186187	ENSG00000169139
Uniprot IDs		Q8ND25	A0M8W4 Q15819
PDB IDs		5YWR	1J74 1J7D 1ZGU 3VON 4NR3 4NRG 4NRI 4ONL 4ONM 4ONN 4ORH 5AIT 7BBD 7BBF
Enriched GO Terms of Interacting Partners?
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