PLXDC2 and ZBP1

Number of citations of the paper that reports this interaction (PubMedID 21903422)
143

Data Source:
BioGRID (affinity chromatography technology, pull down)

		PLXDC2	ZBP1
Description		plexin domain containing 2	Z-DNA binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Integral Component Of Membrane	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Binding	DNA Binding Left-handed Z-DNA Binding Double-stranded RNA Binding Double-stranded RNA Adenosine Deaminase Activity Protein Binding
	Biological Process		Activation Of Innate Immune Response Apoptotic Process Positive Regulation Of Apoptotic Process Innate Immune Response Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Positive Regulation Of Necroptotic Process Pyroptosis Regulation Of Interleukin-1-mediated Signaling Pathway
Pathways			ZBP1(DAI) mediated induction of type I IFNs IRF3 mediated activation of type 1 IFN IRF3 mediated activation of type 1 IFN RIP-mediated NFkB activation via ZBP1 Regulation of innate immune responses to cytosolic DNA Potential therapeutics for SARS
Drugs
Diseases
GWAS		Abdominal aortic calcification levels ( 31659325) Activated partial thromboplastin time ( 29403010) Blood protein levels ( 30072576 29875488 28240269) Bone mineral density (Ward's triangle area) ( 27397699) Bronchopulmonary dysplasia ( 23897914) Diabetic retinopathy ( 21310492) Hair color ( 26926045) Heel bone mineral density ( 30598549 28869591) NHDL cholesterol levels ( 32902719) Nicotine dependence and major depression (severity of comorbidity) ( 30287806) Photic sneeze reflex ( 27182965) Plasma factor V levels in venous thrombosis ( 31271701) Plasma factor V levels in venous thrombosis (conditioned on rs6027) ( 31271701) Proteinuria and chronic kidney disease ( 26420894) Prothrombin time ( 29403010) Pulse pressure ( 27841878 30578418) Retinal detachment or retinal break ( 31816047) Total cholesterol levels ( 32902719)	Hippocampal atrophy ( 19668339) Response to fenofibrate (adiponectin levels) ( 23149075) Verbal declarative memory ( 25648963)
Interacting Genes		2 interacting genes: CLK1 ZBP1	9 interacting genes: APOE CTBP1 CTBP2 KLHL12 PALD1 PLXDC2 SIAH1 TRAF3 TRIP6
Entrez ID		84898	81030
HPRD ID		08440	09484
Ensembl ID		ENSG00000120594	ENSG00000124256
Uniprot IDs		Q6UX71	Q9H171
PDB IDs			2L4M 2LNB 3EYI 4KA4
Enriched GO Terms of Interacting Partners?
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