KISS1R and KISS1

Number of citations of the paper that reports this interaction (PubMedID 11457843)
321

Data Source:
HPRD (in vitro, in vivo)

		KISS1R	KISS1
Description		KISS1 receptor	KiSS-1 metastasis suppressor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cilium Cell Surface Integral Component Of Membrane Intracellular Membrane-bounded Organelle	Extracellular Region Extracellular Space Cytoplasm Apical Plasma Membrane Neuron Projection Neuronal Cell Body
	Molecular Function	Protein Binding Neuropeptide Receptor Activity G Protein-coupled Peptide Receptor Activity	Protein Binding Kisspeptin Receptor Binding
	Biological Process	G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway	Cytoskeleton Organization G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Negative Regulation Of Cell Population Proliferation Positive Regulation Of Luteinizing Hormone Secretion Positive Regulation Of MAPK Cascade Positive Regulation Of Synaptic Transmission Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Generation Of Ovulation Cycle Rhythm Positive Regulation Of Growth Hormone Secretion
Pathways		Peptide ligand-binding receptors G alpha (q) signalling events	Peptide ligand-binding receptors G alpha (q) signalling events
Drugs		ANZ-100
Diseases
GWAS		Menopause (age at onset) ( 26414677) Sweet taste preference ( 32572145)	Psychosis proneness (hypomanic personality scale and perceptual aberration scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised physical anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (hypomanic personality scale) ( 28525603) Response to cognitive-behavioural therapy in anxiety disorder ( 31123309)
Interacting Genes		3 interacting genes: KISS1 PPP2CA PTPA	9 interacting genes: APP CREBBP KISS1R MMP14 MMP16 MMP2 MMP24 MMP9 UBQLN2
Entrez ID		84634	3814
HPRD ID		09167	04475
Ensembl ID		ENSG00000116014	ENSG00000170498
Uniprot IDs		Q969F8 U3KQ86	Q15726
PDB IDs
Enriched GO Terms of Interacting Partners?
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