AFAP1L2 and SH3PXD2A

Number of citations of the paper that reports this interaction (PubMedID 26446840)
6

Data Source:
BioGRID (pull down, affinity chromatography technology)

		AFAP1L2	SH3PXD2A
Description		actin filament associated protein 1 like 2	SH3 and PX domains 2A
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane	Podosome Cytoplasm Cytosol Cell Junction Cell Projection
	Molecular Function	SH3 Domain Binding Protein Tyrosine Kinase Activator Activity Signaling Adaptor Activity SH2 Domain Binding	Protease Binding Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Phosphatidylinositol-5-phosphate Binding Superoxide-generating NADPH Oxidase Activator Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-4-phosphate Binding
	Biological Process	Inflammatory Response Regulation Of Mitotic Cell Cycle Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Protein Tyrosine Kinase Activity	In Utero Embryonic Development Superoxide Metabolic Process Superoxide Anion Generation Regulation Of Catalytic Activity Osteoclast Fusion
Pathways			Invadopodia formation CDC42 GTPase cycle
Drugs
Diseases
GWAS		Cognitive performance ( 20125193) Left ventricular obstructive tract defect (maternal effect) ( 28468790) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 23823483) Platelet distribution width ( 32888494) Systolic blood pressure ( 29212154)	Atrial fibrillation ( 28416818 28416822 29290336 29892015) Brain morphology (MOSTest) ( 32665545) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Cutaneous malignant melanoma ( 26237428) Diisocyanate-induced asthma ( 25918132) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Intraocular pressure ( 29617998) Ischemic stroke ( 29531354) Ischemic stroke (small-vessel) ( 29531354) Manganese levels ( 26025379) Periventricular white matter hyperintensities ( 32517579) PR interval ( 30046033 32439900) Refractive error ( 32231278) Rheumatoid arthritis ( 30891314) Stroke ( 29531354) Telomere length ( 33941849) Waist circumference adjusted for body mass index ( 28552196) White matter hyperintensities ( 32358547) White matter hyperintensity burden ( 25663218) White matter hyperintensity volume ( 33293549) White matter hyperintensity volume (adjusted for hypertension) ( 33293549) White matter hyperintensity volume x hypertension interaction (2df) ( 33293549)
Interacting Genes		10 interacting genes: ACD APP ATXN1L POT1 RASA1 SH3PXD2A SRC TERF1 TERF2 TINF2	7 interacting genes: ADAM15 AFAP1L2 FASLG KHDRBS1 PAK2 SRC SVIL
Entrez ID		84632	9644
HPRD ID		13902	10228
Ensembl ID		ENSG00000169129	ENSG00000107957
Uniprot IDs		B7Z2Q0 Q8N4X5	B3KPL1 Q5TCZ1
PDB IDs		2COF	2DNU 2EGA 2EGC 2EKH
Enriched GO Terms of Interacting Partners?
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