ZGPAT and CARD9

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		ZGPAT	CARD9
Description		zinc finger CCCH-type and G-patch domain containing	caspase recruitment domain family member 9
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Plasma Membrane	Cytoplasm Cytosol Plasma Membrane CBM Complex Protein-containing Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Metal Ion Binding	Protein Binding Protein Homodimerization Activity Protein Self-association Metal Ion Binding CARD Domain Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Negative Regulation Of Transcription, DNA-templated	Positive Regulation Of Cytokine Production Neutrophil Mediated Immunity I-kappaB Kinase/NF-kappaB Signaling Response To Xenobiotic Stimulus Immunoglobulin Mediated Immune Response Response To Peptidoglycan Response To Muramyl Dipeptide Regulation Of Interleukin-2 Production Positive Regulation Of Chemokine Production Positive Regulation Of Granulocyte Macrophage Colony-stimulating Factor Production Positive Regulation Of Interleukin-17 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Response To Exogenous DsRNA Positive Regulation Of Innate Immune Response Positive Regulation Of JNK Cascade Host-mediated Regulation Of Intestinal Microbiota Composition Defense Response To Gram-positive Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Protein Homooligomerization Defense Response To Virus Antifungal Innate Immune Response Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of T-helper 17 Type Immune Response
Pathways			NOD1/2 Signaling Pathway CLEC7A (Dectin-1) signaling
Drugs
Diseases
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29785011) Apolipoprotein A1 levels ( 33730874) Asthma ( 31619474) Asthma or allergic disease (pleiotropy) ( 29785011) C-reactive protein levels ( 30388399) Crohn's disease ( 28067908) Diverticular disease ( 30177863) Estimated glomerular filtration rate ( 31152163 31015462) High density lipoprotein cholesterol levels ( 31928498) Inflammatory bowel disease ( 28067908 23128233) Lung function (FEV1) ( 28166213) Lymphocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) Prostate cancer ( 31562322 23535732) Refractive error ( 32231278) Ulcerative colitis ( 28067908 21297633) Waist circumference ( 31928498)	Acute insulin response (insulin secretion adjusted) ( 28490609) Ankylosing spondylitis ( 23749187 21743469) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 22936669 21102463) Hip circumference adjusted for BMI ( 34021172) IgA nephropathy ( 25305756) Inflammatory bowel disease ( 28067908 23128233) Joint damage in rheumatoid arthritis ( 26498133) Large artery stroke ( 28265093) Monocyte chemoattractant protein-1 levels ( 23017229) Obesity-related traits ( 23251661) Pediatric autoimmune diseases ( 26301688) Takayasu arteritis ( 33308445) Ulcerative colitis ( 19915572 28067908 20228799 21297633)
Interacting Genes		77 interacting genes: AIMP2 AMOTL2 BEND5 BLZF1 C1D CARD9 CAVIN4 CCDC13 CCDC196 CCDC33 CCDC57 CCHCR1 CCNDBP1 CDCA7L CDR2 CEP57L1 CEP70 CNKSR1 CTNNA1 DHX15 DVL2 DYDC1 EP400 FAM9B GATAD2B GOLGA2 GOLGA6L9 HOOK2 HSF2BP IHO1 IKZF3 KIAA1328 KIFC3 KRT15 KRT31 KRT40 LCA5L LDOC1 LNX1 LZTS1 LZTS2 MID2 MIPOL1 NEBL PHC2 PPP1R13B PRPF3 S100A10 SCNM1 SERTAD3 SNRPA1 SPAG5 SSX2IP STAC3 TADA2B TFIP11 THAP1 THAP6 TLE5 TP53BP2 TRIM14 TRIM27 TRIM54 UBXN11 UPF2 ZBTB8A ZC2HC1B ZNF177 ZNF24 ZNF329 ZNF426 ZNF559-ZNF177 ZNF587 ZNF688 ZNF71 ZSCAN22 ZXDB	138 interacting genes: ABLIM1 AMOTL2 AXIN1 BCL10 BLZF1 C1orf94 C2CD6 CABP2 CARD10 CBX8 CCDC13 CCDC136 CCDC85B CCDC88B CCHCR1 CDC37 CDCA7L CDK2AP1 CEP57L1 CEP70 CSNK2A1 CWF19L2 DAXX DISC1 DUSP13 DVL2 EFHC2 EIF4A3 EIF4E2 FAM124B FAM161A FAM161B FAM50B FAM90A1 FOXD4L1 GAS8 GEM HMBOX1 HOXB5 HSF2BP IHO1 IKZF3 INO80B IQCE KANK2 KCTD9 KIAA0408 KIAA1328 KIF9 KIFC3 KRT15 KRT16 KRT19 KRT31 KRT40 KRT75 KRTAP10-1 KRTAP10-3 KRTAP10-5 KRTAP5-7 L3MBTL2 LENG1 LMO1 LMO3 LNX1 LZTS1 LZTS2 MCRS1 MEOX2 MFAP1 MID2 MYO15B NECAB2 NTAQ1 PAK5 PBX2 PHC2 PIBF1 PICK1 PKP2 PNMA5 PPP1R18 PRPF18 PSMA4 RBAK RTP5 SAXO1 SCNM1 SHISA6 SLAIN1 SSX2IP STMN3 STX11 SUMO1 TASOR2 TCEANC TCL1A TEX33 TFIP11 TLE5 TNFAIP1 TNS4 TRIM14 TRIM23 TRIM29 TRIM42 TRIM54 TRIM62 TSGA10IP TSNAX UBE2I UNKL USH1G USP15 USP2 VCPKMT VPS28 YES1 ZBTB16 ZC2HC1C ZCCHC7 ZGPAT ZMYM5 ZNF121 ZNF19 ZNF20 ZNF250 ZNF417 ZNF426 ZNF572 ZNF587 ZNF620 ZNF655 ZNF688 ZNF774 ZNF829 ZRANB1 ZZZ3
Entrez ID		84619	64170
HPRD ID		15736	06236
Ensembl ID		ENSG00000197114	ENSG00000187796
Uniprot IDs		A0A0S2Z5X3 Q8N5A5	A0A024R8F1 Q9H257
PDB IDs		4II1	6E25 6E26 6E27 6E28 6N2M 6N2P
Enriched GO Terms of Interacting Partners?
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