CYSTM1 and BAG3

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CYSTM1	BAG3
Description		cysteine rich transmembrane module containing 1	BAG cochaperone 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Extracellular Exosome Tertiary Granule Membrane	Stress Fiber Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Aggresome Z Disc Neuron Projection Chaperone Complex
	Molecular Function	Molecular_function Protein Binding	Adenyl-nucleotide Exchange Factor Activity Protein Binding Heat Shock Protein Binding Protein-containing Complex Binding Cadherin Binding Dynein Intermediate Chain Binding Chaperone Binding Protein Carrier Activity
	Biological Process	Biological_process	Autophagosome Assembly Protein Folding Brain Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Striated Muscle Cell Apoptotic Process Spinal Cord Development Cellular Response To Heat Cellular Response To Unfolded Protein Positive Regulation Of Protein Import Into Nucleus Negative Regulation Of Apoptotic Process Muscle Cell Cellular Homeostasis Positive Regulation Of Protein Export From Nucleus Regulation Of Catalytic Activity Protein Stabilization Chaperone-mediated Autophagy Aggresome Assembly Cellular Response To Mechanical Stimulus Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Protein Transport Along Microtubule Negative Regulation Of Protein Targeting To Mitochondrion Positive Regulation Of Aggrephagy
Pathways		Neutrophil degranulation	Regulation of HSF1-mediated heat shock response
Drugs
Diseases
GWAS		Body mass index ( 26426971) Intelligence (MTAG) ( 29326435) Low density lipoprotein cholesterol levels ( 32154731) Worry too long after an embarrassing experience ( 29500382)	Aspartate aminotransferase levels ( 33547301) Diastolic blood pressure ( 27841878) Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart failure ( 31919418) Hypertrophic cardiomyopathy ( 33495596 33495597) Hypertrophic cardiomyopathy (MTAG) ( 33495596) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Idiopathic dilated cardiomyopathy ( 21459883) Left ventricular ejection fraction ( 33495596 32382064 32605384) Left ventricular end-diastolic volume ( 33495596) Left ventricular end-systolic volume ( 33495596 32382064) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Parkinson's disease ( 32201043 27182965 28892059) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)
Interacting Genes		4 interacting genes: BAG3 GLP1R SLC22A1 SYT16	75 interacting genes: ACD ARRDC3 ATN1 ATXN7L2 BAIAP2L1 BCL2 CRYAB CTDSP1 CYSRT1 CYSTM1 DAZAP2 DNM2 DTX3 DVL1 DVL2 DYNLT1 EGR4 EYA2 FAM168B FAM189A2 FBXO7 FOXD4L1 GGN GLIS3 HELT HSPA1A HSPA5 HSPA8 HSPB1 HSPB2 HSPB2-C11orf52 HSPB7 HSPB8 INCA1 LENG8 LITAF LRRK1 LRRK2 MAGED1 MDFI MRPL38 NIBAN3 NOTO NR1H3 PDE9A PDLIM7 PIH1D2 PLA2G10 PLCG1 PLEKHB1 POT1 PRDM6 PRKAR1B PRR34 PTPN21 RUNX1 SF3B4 SHISA6 SIAH1 SPRY2 SRPK2 TBC1D3B TBC1D3G TINF2 TMEM174 TNK2 TP53BP2 TRIB3 TRIM27 TRIP6 TSC1 UNKL VPS37B WBP2 WNK1
Entrez ID		84418	9531
HPRD ID		15091	04860
Ensembl ID		ENSG00000120306	ENSG00000151929
Uniprot IDs		Q9H1C7	O95817
PDB IDs
Enriched GO Terms of Interacting Partners?
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