AKT1S1 and FZR1

Number of citations of the paper that reports this interaction (PubMedID 28205554)
52

Data Source:
BioGRID (fluorescent resonance energy transfer)

		AKT1S1	FZR1
Description		AKT1 substrate 1	fizzy and cell division cycle 20 related 1
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol	Nucleoplasm Anaphase-promoting Complex Cytosol Nuclear Membrane
	Molecular Function	Protein Binding	Protein Binding Anaphase-promoting Complex Binding Ubiquitin Ligase Activator Activity
	Biological Process	Negative Regulation Of Protein Kinase Activity Negative Regulation Of TOR Signaling Regulation Of Apoptotic Process Regulation Of Neuron Apoptotic Process Negative Regulation Of Cell Size Neurotrophin TRK Receptor Signaling Pathway	DNA Repair Mitotic G2 DNA Damage Checkpoint Signaling Positive Regulation Of Cell Population Proliferation Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Meiotic Nuclear Division Positive Regulation Of Protein Catabolic Process Cell Division Lens Fiber Cell Differentiation Protein K11-linked Ubiquitination Negative Regulation Of Cell Aging Positive Regulation Of Ubiquitin Protein Ligase Activity Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
Pathways		MTOR signalling mTORC1-mediated signalling AKT phosphorylates targets in the cytosol HSF1-dependent transactivation Constitutive Signaling by AKT1 E17K in Cancer	Autodegradation of Cdh1 by Cdh1:APC/C SCF-beta-TrCP mediated degradation of Emi1 APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase Phosphorylation of Emi1 Senescence-Associated Secretory Phenotype (SASP) CDK-mediated phosphorylation and removal of Cdc6 Cyclin A:Cdk2-associated events at S phase entry Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS			Red cell distribution width ( 32888494)
Interacting Genes		9 interacting genes: AKT1 AKT2 EIF6 FZR1 MTOR RPS6KA5 TCEA2 YWHAG YWHAQ	87 interacting genes: AKT1S1 ANAPC1 ANAPC11 ANAPC2 ANAPC5 ANAPC7 ARNT AURKA BECN1 BEX1 BLID BTRC C7orf25 CCL5 CCNB1 CCND2 CCNE1 CCNF CDC14A CDC27 CDC6 CDK2 CDK4 CDK5 CDK6 CDKN2B CDR2 CDT1 CLSPN CYP17A1 DCPS DKK3 DNAJA1 DNM1L E2F3 EPHA2 EPSTI1 ERBB2 FBXO5 FGFR4 GLIS2 GMNN HECW2 HIF1A KAT2A KIF18B LATS2 MAD2L2 MAK MAP2K3 MAP2K5 MAP3K5 MAPK8 MET MOAP1 MTA3 MYC NAT2 NEDD9 NEK2 NF2 OTUD7B PAX3 PDGFRA PSMC3IP PTP4A3 PTTG1 RASSF1 RBBP8 SASS6 SENP2 SIRT2 SKIL SKP2 SMURF1 SOX2 SOX4 SRC STK11 TEAD2 TERT THRSP TTF2 UBE2D1 UBE2D3 UBE2K UHRF1
Entrez ID		84335	51343
HPRD ID		12441	04687
Ensembl ID		ENSG00000204673	ENSG00000105325
Uniprot IDs		A0A024QZF6 Q96B36	Q9UM11
PDB IDs		5WBL 5WBU 5WBY 6SB0	4UI9 5L9T 5L9U
Enriched GO Terms of Interacting Partners?
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