CASP7 and SLC30A9

		CASP7	SLC30A9
Description		caspase 7	solute carrier family 30 member 9
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol	Nucleus Endoplasmic Reticulum Cytoskeleton Integral Component Of Membrane Cytoplasmic Vesicle
	Molecular Function	Aspartic-type Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis	Chromatin Binding Cation Transmembrane Transporter Activity Nuclear Receptor Binding Nuclear Receptor Coactivator Activity
	Biological Process	Proteolysis Apoptotic Process Heart Development Aging Response To UV Protein Processing Striated Muscle Cell Differentiation Neuron Apoptotic Process Leukocyte Apoptotic Process Cellular Response To Staurosporine Execution Phase Of Apoptosis	Nucleotide-excision Repair Zinc Ion Transport Cellular Zinc Ion Homeostasis Positive Regulation Of Transcription By RNA Polymerase II Cation Transmembrane Transport
Pathways		Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes Apoptotic cleavage of cellular proteins SMAC, XIAP-regulated apoptotic response Caspase-mediated cleavage of cytoskeletal proteins
Drugs		Fica Emricasan Incadronic acid
Diseases
GWAS		Cataracts ( 34127677) Smoking status (ever vs never smokers) ( 30643258) Vitiligo ( 27723757 22561518)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Depression ( 29700475) Helping behaviour (self reported) ( 29324852) Opioid exposure ( 32099098)
Interacting Genes		63 interacting genes: AR ARHGDIA BIRC2 BIRC3 BIRC5 BIRC6 BIRC7 CASP10 CASP2 CASP3 CASP8 CASP9 CAST CDC42 CFLAR CLSPN COPS6 CTSG DCTN1 DFFA DSP EIF2AK2 GOLGA3 GORASP1 GZMB HSPA5 KRT18 LYN MAGEA11 MAPT MAX MEF2A MEF2D NEDD4 NIF3L1 PARP1 PLA2G4B PRKCZ PSEN1 PSEN2 PSIP1 PSME3 PTGES3 PTMA RAC1 RAD21 RAD51 RASA1 RB1 RNF7 ROCK1 SAT1 SLC30A9 SP1 SPTAN1 SRF STAT1 STK24 TERF1 TNFRSF1A UBE4B VIM XIAP	7 interacting genes: CASP7 CORIN ESR1 NCOA2 NPR3 PTTG2 TXNRD2
Entrez ID		840	10463
HPRD ID		03457	06858
Ensembl ID		ENSG00000165806	ENSG00000014824
Uniprot IDs		A0A0A0MRL7 B4DWA2 P55210	A0A0S2Z514 Q6PML9
PDB IDs		1F1J 1GQF 1I4O 1I51 1K86 1K88 1KMC 1MIA 1SHJ 1SHL 2QL5 2QL7 2QL9 2QLB 2QLF 2QLJ 3EDR 3H1P 3IBC 3IBF 3R5K 4FDL 4FEA 4HQ0 4HQR 4JB8 4JJ8 4JR1 4JR2 4LSZ 4ZVO 4ZVP 4ZVQ 4ZVR 4ZVS 4ZVT 4ZVU 5IC6 5K20 5V6U 5V6Z	2ENK
Enriched GO Terms of Interacting Partners?
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