H4C14 and SET

Number of citations of the paper that reports this interaction (PubMedID 11163245)
177

Data Source:
HPRD (in vitro, in vivo)

		H4C14	SET
Description		H4 clustered histone 14	SET nuclear proto-oncogene
Image
GO Annotations	Cellular Component	Nuclear Chromosome Chromosome, Telomeric Region Nucleosome Extracellular Region Nucleus Nucleoplasm Membrane Protein-containing Complex Extracellular Exosome	Chromatin Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol Protein-containing Complex Perinuclear Region Of Cytoplasm
	Molecular Function	DNA Binding RNA Binding Protein Binding Protein Domain Specific Binding Protein Heterodimerization Activity	DNA Binding Chromatin Binding Protein Phosphatase Inhibitor Activity Protein Binding Protein Phosphatase Regulator Activity Histone Binding
	Biological Process	Nucleosome Assembly DNA Replication-dependent Nucleosome Assembly DNA Replication-independent Nucleosome Assembly DNA-templated Transcription, Initiation Telomere Organization Negative Regulation Of Megakaryocyte Differentiation	DNA Replication Nucleosome Assembly Nucleosome Disassembly Negative Regulation Of Histone Acetylation Negative Regulation Of Catalytic Activity Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Transcription, DNA-templated
Pathways		Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones PKMTs methylate histone lysines HDMs demethylate histones HATs acetylate histones HATs acetylate histones RMTs methylate histone arginines SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression SUMOylation of chromatin organization proteins B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Amyloid fiber formation	Condensation of Prophase Chromosomes HuR (ELAVL1) binds and stabilizes mRNA
Drugs
Diseases
GWAS			Axial length ( 24144296) Body mass index ( 26426971) Eating disorders (purging via substances) ( 23568457)
Interacting Genes		27 interacting genes: ASF1A ATAD2 BRD4 BRDT DNMT3L EP300 H2AC20 H3C1 HAT1 KAT2A KAT5 LBR NAP1L4 PRMT1 PTMA RAD51B RBBP4 RNF20 RPS6KA5 SET TAF15 TBL1X TBL1XR1 TP53BP1 UCHL5 UHRF1 YWHAQ	69 interacting genes: ANP32A APEX1 APP CALM1 CDCA8 CDK5 CDK5R1 CDKN1A CHAF1A CHRM2 CHRM3 ELAVL1 ELF4 ENO1 EP300 ESR1 FAM111B FBXO7 FOS FOXO1 GZMA GZMK H1-1 H2BC1 H3-3A H3-4 H4-16 H4C14 HMGB2 IRF1 JUNB KLF5 KMT2A LGMN MDM2 MEOX2 MTERF1 NME1 NUCB1 NUPR1 PAX6 PIK3CG PPP2CA PPP2R1B PRKAR1A PTEN PTMA RAC1 REPIN1 SDCBP SETBP1 SGO1 SGO2 TAF1A TERF1 TERF2 TERF2IP TEX35 THAP7 TLE5 TREX1 TRIM55 TRIM63 UBE3A UCHL5 XRCC6 ZNF17 ZNF438 ZNF85
Entrez ID		8370	6418
HPRD ID		11821	09023
Ensembl ID		ENSG00000270882	ENSG00000119335
Uniprot IDs		B2R4R0 P62805	A0A024R895 A0A0C4DFV9 Q01105 Q5VXV3
PDB IDs		1ZKK 2BQZ 2CV5 2IG0 2KWN 2KWO 2LVM 2QQS 2RJE 2RNY 2RS9 3A6N 3AFA 3AN2 3AV1 3AV2 3AYW 3AZE 3AZF 3AZG 3AZH 3AZI 3AZJ 3AZK 3AZL 3AZM 3AZN 3CFS 3CFV 3F9W 3F9X 3F9Y 3F9Z 3IJ1 3JPX 3NQJ 3NQU 3O36 3QBY 3QZS 3QZT 3QZV 3R45 3UVW 3UVX 3UVY 3UW9 3W96 3W97 3W98 3W99 3WA9 3WAA 3WKJ 3WTP 3X1S 3X1T 3X1U 3X1V 4GQB 4H9N 4H9O 4H9P 4H9Q 4H9R 4H9S 4HGA 4M38 4N3W 4N4F 4QUT 4QUU 4QYD 4U9W 4YM5 4YM6 4YY6 4YYD 4YYG 4YYH 4YYI 4YYJ 4YYK 4YYM 4YYN 4Z2M 4Z5T 5AV5 5AV6 5AV8 5AV9 5AVB 5AVC 5AY8 5B0Y 5B0Z 5B24 5B2I 5B2J 5B31 5B32 5B33 5B40 5BNV 5BNX 5BO0 5C3I 5CPI 5CPJ 5CPK 5FA5 5FFW 5FWE 5GSE 5GSU 5GT0 5GT3 5GTC 5GXQ 5JA4 5JRG 5KDM 5TEG 5X7X 5XF3 5XF4 5XF5 5Y0C 5Y0D 5YE3 5YE4 5Z23 5Z30 5ZBX 5ZGC 6A5L 6A5O 6A5P 6A5R 6A5T 6A5U 6ACP 6BUZ 6C0W 6E0C 6E0P 6FML 6HKT 6HTS 6INQ 6IR9 6J4W 6J4X 6J4Y 6J4Z 6J50 6J51 6JOU 6JR0 6JR1 6K1I 6K1J 6K1K 6KE9 6KVD 6KXV 6L49 6L4A 6L9H 6L9Z 6LA2 6LA8 6LA9 6LAB 6LE9 6LER 6M3V 6M44 6M4D 6M4G 6M4H 6MLC 6MUO 6MUP 6O1D 6R0C 6R8Y 6R8Z 6R90 6R91 6R92 6R93 6R94 6RNY 6RXS 6SE0 6SE6 6SEE 6SEF 6SEG 6T79 6T7A 6T7B 6T7C 6T7D 6T90 6T93 6UPK 6UPL 6USJ 6V2K 6V92 6VO5 6X59 6X5A 6XJD 6Y5D 6YOV 7A08 7BXT 7BY0 7C0M 7CCQ 7CCR 7D1Z 7D20 7DBP 7JO9 7JOA 7JZV 7K5X 7K5Y 7K60 7K61 7K63 7LMK 7LMM	2E50
Enriched GO Terms of Interacting Partners?
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