CAMK2G and ADCY3

Number of citations of the paper that reports this interaction (PubMedID 9768837)
64

Data Source:
HPRD (in vivo)

		CAMK2G	ADCY3
Description		calcium/calmodulin dependent protein kinase II gamma	adenylate cyclase 3
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytosol Calcium- And Calmodulin-dependent Protein Kinase Complex Membrane Endocytic Vesicle Membrane Sarcoplasmic Reticulum Membrane Neuron Projection	Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Cilium Membrane Integral Component Of Membrane Ciliary Membrane
	Molecular Function	Calmodulin-dependent Protein Kinase Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Calmodulin Binding ATP Binding Identical Protein Binding Protein Homodimerization Activity Protein Serine Kinase Activity	Adenylate Cyclase Activity Calmodulin Binding ATP Binding Metal Ion Binding
	Biological Process	Protein Phosphorylation Protein Dephosphorylation Nervous System Development Regulation Of Neuron Projection Development Regulation Of Skeletal Muscle Adaptation Insulin Secretion Cell Differentiation Regulation Of Calcium Ion Transport	CAMP Biosynthetic Process Signal Transduction Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Single Fertilization Acrosome Reaction Sensory Perception Of Smell Olfactory Learning Flagellated Sperm Motility Intracellular Signal Transduction Cellular Response To Forskolin
Pathways		CaMK IV-mediated phosphorylation of CREB HSF1-dependent transactivation Trafficking of AMPA receptors Unblocking of NMDA receptors, glutamate binding and activation Unblocking of NMDA receptors, glutamate binding and activation CREB1 phosphorylation through the activation of CaMKII/CaMKK/CaMKIV cascasde Ras activation upon Ca2+ influx through NMDA receptor Phase 0 - rapid depolarisation Ion homeostasis RAF activation RAF/MAP kinase cascade Signaling by moderate kinase activity BRAF mutants Signaling by BRAF and RAF1 fusions Paradoxical activation of RAF signaling by kinase inactive BRAF Interferon gamma signaling Regulation of MECP2 expression and activity Ion transport by P-type ATPases Assembly and cell surface presentation of NMDA receptors Negative regulation of NMDA receptor-mediated neuronal transmission Long-term potentiation Signaling downstream of RAS mutants Signaling by RAF1 mutants	Glucagon signaling in metabolic regulation PKA activation PKA activation in glucagon signalling Adenylate cyclase activating pathway Adenylate cyclase inhibitory pathway Adenylate cyclase inhibitory pathway G alpha (s) signalling events G alpha (s) signalling events G alpha (i) signalling events G alpha (z) signalling events G alpha (z) signalling events Vasopressin regulates renal water homeostasis via Aquaporins Hedgehog 'off' state ADORA2B mediated anti-inflammatory cytokines production ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis
Drugs		Bosutinib 1-tert-butyl-3-(3-methylbenzyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Fostamatinib
Diseases
GWAS		Body size at age 10 ( 32376654) Chronic obstructive pulmonary disease or resting heart rate (pleiotropy) ( 30940143) Crohn's disease ( 28067908) FEV1 ( 30804560) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lung function (FEV1/FVC) ( 30804560) Lung function (FVC) ( 30804560) Multiple sclerosis ( 31604244) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Peak expiratory flow ( 30804560) Psoriasis ( 25939698) Psoriasis vulgaris ( 26626624) Systemic lupus erythematosus ( 28714469) Type 2 diabetes ( 30054458)	Adult body size ( 32376654) BMI (adjusted for smoking behaviour) ( 28443625) BMI at 1 year old ( 31575865) BMI at 1.5 years old ( 31575865) BMI at 2 years old ( 31575865) BMI at 3 years old ( 31575865) BMI at 5 years old ( 31575865) BMI at 6 months old ( 31575865) BMI at 8 months old ( 31575865) BMI in non-smokers ( 28443625) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Body fat mass ( 28552196) Body mass index ( 28552196 22344219 29381148 26426971 26961502 24861553 31453325 28892062 25673413 20935630 29273807 23583978 28448500 25953783) Body mass index (adult) ( 28430825) Body mass index (age <50) ( 26426971) Body mass index (age>50) ( 26426971) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in non-asthmatics ( 23517042) Body mass index in physically active individuals ( 28448500) Body mass index in physically inactive individuals ( 28448500) Body mass index variance ( 31453325) Body mass index x sex x age interaction (4df test) ( 26426971) Body size at age 10 ( 32376654) Breast cancer ( 29059683) Childhood body mass index ( 33045005 26604143) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Chronotype ( 30696823) Coronary artery disease ( 29212778) Crohn's disease ( 28067908) Dentures ( 31235808) Diastolic blood pressure ( 28135244 27841878 30578418) Hand grip strength ( 29691431) Height ( 28552196 23563607 31562340 18391951) Height adjusted BMI ( 25044758) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 27863252) Hip circumference ( 31453325 25673412) Hip circumference adjusted for BMI ( 34021172) Hip circumference variance ( 31453325) Inflammatory bowel disease ( 28067908 23128233) Multiple sclerosis ( 31604244) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Obese vs. thin ( 30677029) Obesity ( 23563607) Obesity (extreme) ( 30677029) Pubertal anthropometrics ( 23449627) Response to antidepressants (symptom improvement) ( 33589590) Reticulocyte count ( 32888494 27863252) Systolic blood pressure ( 27841878 30578418) Trunk fat mass ( 28552196) Type 1 diabetes ( 21980299) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		53 interacting genes: ACTN2 ACTN4 ADCY3 ARID5B ATF1 CABP2 CALM1 CAMK2A CAMK2B CAMK2D CDC37 CHAT CREM DUS1L EGFR ESRRG FLNA FXR1 FXR2 GRIA1 GRIA4 GRIN1 GRIN2B KANK2 KRTAP19-3 KRTAP6-1 KRTAP6-3 LRRC7 MRPL11 MYLK NUTF2 NXF1 PEA15 PLCB3 PSMB1 PTEN RCHY1 RRAD RYR1 SMAD2 SMAD3 SMAD4 SPR STAT1 STMN1 STRBP SYN1 TH TIAM1 TNPO2 TNPO3 TTC5 UBE2I	3 interacting genes: CAMK2G MTNR1B STOML3
Entrez ID		818	109
HPRD ID		03672	02620
Ensembl ID		ENSG00000148660	ENSG00000138031
Uniprot IDs		A0A2Q3DQE3 B3KY86 Q13280 Q13555 Q5SWX3	A0A0A0MSC1 B7ZLX9 O60266
PDB IDs		2UX0 2V7O
Enriched GO Terms of Interacting Partners?
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