SNX27 and PNPLA3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
87

Data Source:
BioGRID (two hybrid)

		SNX27	PNPLA3
Description		sorting nexin 27	patatin like phospholipase domain containing 3
Image			No pdb structure
GO Annotations	Cellular Component	Immunological Synapse Nucleoplasm Endosome Early Endosome Cytosol Early Endosome Membrane	Cytoplasm Endoplasmic Reticulum Membrane Lipid Droplet Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding	1-acylglycerol-3-phosphate O-acyltransferase Activity Lipoprotein Lipase Activity Phospholipase A2 Activity Triglyceride Lipase Activity Acylglycerol O-acyltransferase Activity Lysophosphatidic Acid Binding Long-chain Fatty Acyl-CoA Binding Lysophosphatidic Acid Acyltransferase Activity Mono-olein Transacylation Activity Diolein Transacylation Activity
	Biological Process	Establishment Of Natural Killer Cell Polarity Intracellular Protein Transport Signal Transduction Endosome To Lysosome Transport Endosomal Transport Endocytic Recycling	Long-chain Fatty Acid Metabolic Process Glycerophospholipid Metabolic Process Phosphatidic Acid Biosynthetic Process Response To Sucrose Triglyceride Biosynthetic Process Triglyceride Catabolic Process Cellular Response To Insulin Stimulus Lipid Droplet Organization Triglyceride Acyl-chain Remodeling Acylglycerol Acyl-chain Remodeling White Fat Cell Differentiation Lipid Homeostasis Cellular Response To 3,3',5-triiodo-L-thyronine
Pathways			Acyl chain remodeling of DAG and TAG
Drugs
Diseases
GWAS		Body mass index ( 26426971)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Alanine aminotransferase levels ( 30718733 31219225 33547301 34315874 33339817) Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Alanine transaminase levels ( 29403010) Apolipoprotein A1 levels ( 32203549) Aspartate aminotransferase levels ( 31219225 33547301 34315874 29403010 33339817) Cirrhosis ( 31815349) Cirrhosis (alcohol related) ( 26482880 32853455) Cirrhosis (multi-trait analysis) ( 33310085) Gout ( 33832965) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549) Hematocrit ( 32888494 27863252) Hematological and biochemical traits ( 20139978) Hemoglobin ( 32888494) Hemoglobin concentration ( 27863252) Hemoglobin levels ( 32327693) Hepatic lipid content in extreme obesity ( 25246029) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 33972514 22001757) Liver fat content (MRI proton density fat fraction measure) ( 32247823) Liver fibrosis and steatohepatitis severity (MRI cT1 measure) ( 32247823) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494) Mean platelet volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Metabolite levels ( 21909109) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Non-alcoholic fatty liver disease activity score in non-alcoholic fatty liver disease ( 31311600) Nonalcoholic fatty liver disease ( 32298765 21423719 24531328 22719876 29271184 29385134 31311600) Nonalcoholic steatohepatitis ( 32298765) Nonalcoholic steatohepatitis-derived hepatocellular carcinoma ( 29385134) Pediatric non-alcoholic fatty liver disease activity score ( 23535911) Percent liver fat ( 34128465) Platelet count ( 29403010 32888494 27863252) Plateletcrit ( 32888494 27863252) Red cell distribution width ( 32888494 27863252 28957414) Serum uric acid levels ( 30993211) Total cholesterol levels ( 33339817 31217584 30275531) Total triglycerides levels ( 26690388) Triacylglycerol 56:6 levels ( 31560688) Type 2 diabetes ( 30297969 29632382) Type 2 diabetes (adjusted for BMI) ( 29632382) Urate levels ( 31578528)
Interacting Genes		10 interacting genes: ACE2 AKT2 APP DGKZ HLCS PNPLA3 PTEN RPS6KA1 SELP SUMO2	4 interacting genes: AKT2 FLT3 LINC00839 SNX27
Entrez ID		81609	80339
HPRD ID		11591	12430
Ensembl ID		ENSG00000143376	ENSG00000100344
Uniprot IDs		A0A2R8Y8A7 Q96L92	Q9NST1
PDB IDs		4HAS 5ZN9 6SAK
Enriched GO Terms of Interacting Partners?
Tagcloud ?
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