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NECTIN4 and TIGIT

  • Number of citations of the paper that reports this interaction (PubMedID 21982860)
  • 20
  • Data Source:
  • BioGRID (pull down)

NECTIN4

TIGIT

Description nectin cell adhesion molecule 4 T cell immunoreceptor with Ig and ITIM domains
Image
GO Annotations Cellular Component
  • Plasma Membrane
  • Adherens Junction
  • Integral Component Of Membrane
  • Extracellular Exosome
  • Plasma Membrane
  • Cell Surface
  • Integral Component Of Membrane
Molecular Function
  • Virus Receptor Activity
  • Protein Binding
  • Identical Protein Binding
  • Signaling Receptor Binding
  • Protein Binding
  • Identical Protein Binding
Biological Process
  • Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules
  • Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules
  • Viral Entry Into Host Cell
  • Negative Regulation Of Interleukin-12 Production
  • Positive Regulation Of Interleukin-10 Production
  • Negative Regulation Of T Cell Activation
Pathways
  • Adherens junctions interactions
  • Nectin/Necl trans heterodimerization
Drugs
  • Enfortumab vedotin
Diseases
GWAS
Interacting Genes 6 interacting genes: AFDN DEFB121 NECTIN1 NECTIN2 PICK1 TIGIT 11 interacting genes: B4GALT4 CCDC191 GRAMD1C MAL NECTIN2 NECTIN3 NECTIN4 PLLP PVR QTRT2 ZDHHC23
Entrez ID 81607 201633
HPRD ID 17934 08804
Ensembl ID ENSG00000143217 ENSG00000181847
Uniprot IDs K4PZ75 Q96NY8 Q495A1
PDB IDs 4FRW 4GJT 4JJH 3Q0H 3RQ3 3UCR 3UDW 5V52
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?

© Madhavi K. Ganapathiraju 2012-2025