CALR and MBL2

Number of citations of the paper that reports this interaction (PubMedID 8062452)
20

Data Source:
HPRD (in vivo, in vitro)

		CALR	MBL2
Description		calreticulin	mannose binding lectin 2
Image
GO Annotations	Cellular Component	Acrosomal Vesicle Extracellular Region Extracellular Space Nucleus Nuclear Envelope Cytoplasm Lysosome Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Smooth Endoplasmic Reticulum Golgi Apparatus Cytosol Polysome Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Phagocytic Vesicle Membrane Sarcoplasmic Reticulum Lumen Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane MHC Class I Peptide Loading Complex Endoplasmic Reticulum Quality Control Compartment Perinuclear Region Of Cytoplasm Cortical Granule Collagen-containing Extracellular Matrix Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane Endocytic Vesicle Lumen	Extracellular Region Collagen Trimer Extracellular Space Cell Surface Collagen-containing Extracellular Matrix
	Molecular Function	Complement Component C1q Complex Binding DNA Binding RNA Binding MRNA Binding Integrin Binding Iron Ion Binding Calcium Ion Binding Protein Binding Zinc Ion Binding Carbohydrate Binding Ubiquitin Protein Ligase Binding Peptide Binding Hormone Binding Protein Folding Chaperone Androgen Receptor Binding Unfolded Protein Binding Chaperone Binding	Signaling Receptor Binding Protein Binding Mannose Binding Identical Protein Binding Calcium-dependent Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Peptide Antigen Assembly With MHC Class I Protein Complex Regulation Of Transcription, DNA-templated Protein Folding Protein Export From Nucleus Cellular Calcium Ion Homeostasis Spermatogenesis Positive Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Positive Regulation Of Endothelial Cell Migration Positive Regulation Of Gene Expression Negative Regulation Of Translation Protein Maturation By Protein Folding Ubiquitin-dependent ERAD Pathway Cortical Actin Cytoskeleton Organization Response To Estradiol Negative Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Response To Testosterone Protein Localization To Nucleus Protein Folding In Endoplasmic Reticulum Regulation Of Meiotic Nuclear Division Glucocorticoid Receptor Signaling Pathway Regulation Of Apoptotic Process Negative Regulation Of Neuron Differentiation Positive Regulation Of Cell Cycle Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Phagocytosis Protein Stabilization Sequestering Of Calcium Ion Regulation Of Cell Cycle Cardiac Muscle Cell Differentiation Cellular Response To Lithium Ion Cellular Senescence Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Negative Regulation Of Trophoblast Cell Migration Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Dendritic Cell Chemotaxis	Complement Activation, Lectin Pathway Acute-phase Response Complement Activation, Classical Pathway Response To Oxidative Stress Opsonization Defense Response To Bacterium Innate Immune Response Negative Regulation Of Viral Process Defense Response To Gram-positive Bacterium
Pathways		ER-Phagosome pathway Assembly of Viral Components at the Budding Site Scavenging by Class A Receptors Scavenging by Class A Receptors Scavenging by Class F Receptors Scavenging by Class F Receptors ATF6 (ATF6-alpha) activates chaperone genes Calnexin/calreticulin cycle Antigen Presentation: Folding, assembly and peptide loading of class I MHC	Lectin pathway of complement activation Initial triggering of complement
Drugs		Antihemophilic factor, human recombinant Tenecteplase Melatonin Lanoteplase Copper Calcium citrate Calcium Phosphate Lonoctocog alfa Moroctocog alfa Calcium phosphate dihydrate	O3-Sulfonylgalactose Methyl alpha-D-mannoside 4-(Hydrogen sulfate)-beta-D-galactopyranose Methyl beta-L-fucopyranoside N-acetyl-alpha-neuraminic acid alpha-L-methyl-fucose Alpha-Methyl-N-Acetyl-D-Glucosamine
Diseases
GWAS		Clozapine-induced agranulocytosis ( 25187353) Estimated glomerular filtration rate ( 31152163) Platelet count ( 32888494) Red blood cell traits ( 23222517)	Age-related macular degeneration ( 23326517) Blood protein levels ( 30072576 29875488 28240269) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) Chin dimples ( 27182965) Emphysema imaging phenotypes ( 26030696) Femoral neck bone mineral density ( 29499414) Fractures ( 30158200 30598549) Heel bone mineral density ( 30598549 28869591) Lumbar spine bone mineral density ( 29499414 22504420) Metabolite levels ( 23823483) Monobrow ( 27182965) Rosacea symptom severity ( 29771307)
Interacting Genes		54 interacting genes: APOB APP AR B2M CD1D F5 F8 FBN1 FGB GSC2 HLA-A HLA-C HLA-E ICAM1 ICAM3 ITGA2B ITGA3 ITGAV ITIH1 LPL LRIF1 LRP1 MAPK6 MBL2 MTNR1A NKX2-1 NR3C1 OGT PDIA2 PDIA3 PLAT PLP1 PRF1 PTPN11 RNY1 RNY3 RNY4 SCARF1 SGTB SIRPA SLC2A1 SLC6A4 SMARCB1 SQSTM1 SUMO4 TAF1B TAPBP TF THBS1 TRIM21 TSHR UBE3A UPF2 VWF	10 interacting genes: ANK3 CALCR CALR CD93 KRT1 MAD2L1 MASP1 MASP2 PTPRC UBQLN2
Entrez ID		811	4153
HPRD ID		00169	01107
Ensembl ID		ENSG00000179218	ENSG00000165471
Uniprot IDs		P27797 V9HW88	P11226
PDB IDs		2CLR 3DOW 3POS 3POW 5LK5 5V90 6ENY	1HUP
Enriched GO Terms of Interacting Partners?
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