COLEC12 and EXOSC2

		COLEC12	EXOSC2
Description		collectin subfamily member 12	exosome component 2
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GO Annotations	Cellular Component	Collagen Trimer Extracellular Space Plasma Membrane Integral Component Of Membrane Endocytic Vesicle Membrane Extracellular Matrix	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol
	Molecular Function	Scavenger Receptor Activity Galactose Binding Low-density Lipoprotein Particle Binding Pattern Recognition Receptor Activity Metal Ion Binding	3'-5'-exoribonuclease Activity RNA Binding Exoribonuclease Activity Protein Binding 7S RNA Binding
	Biological Process	Phagocytosis, Recognition Defense Response Carbohydrate Mediated Signaling Toll-like Receptor 3 Signaling Pathway Defense Response To Bacterium Innate Immune Response Positive Regulation Of Cell Adhesion Molecule Production Cellular Response To Exogenous DsRNA	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Exonucleolytic Catabolism Of Deadenylated MRNA CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Retention Of Pre-mRNA With Aberrant 3'-ends At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Scavenging by Class A Receptors	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Bipolar disorder ( 20351715) Bipolar disorder or major depressive disorder ( 20351715) Blood protein levels ( 30072576 29875488) Coenzyme Q10 levels ( 27149984) Metabolic syndrome ( 29212154) Obesity-related traits ( 23251661) Schizophrenia x sex interaction ( 34099189) Smoking status (ever vs never smokers) ( 30643258)
Interacting Genes		6 interacting genes: APP EXOC1 EXOSC2 FBXO7 PTPN2 ZBTB14	29 interacting genes: ADAMTS13 AMBP ANGPTL2 CACFD1 COLEC12 DIS3 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FBXW2 GALNT13 KHSRP KIFBP MRPL48 MTREX MTX2 NCS1 NELFB PALS2 PTEN RNF8 SBK3 ST6GALNAC1 UPF1 VCAM1 ZNF408
Entrez ID		81035	23404
HPRD ID		06358	03758
Ensembl ID		ENSG00000158270	ENSG00000130713
Uniprot IDs		Q5KU26	B3KQW2 Q13868
PDB IDs		2OX8	2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
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