CALML3 and IL2RA

		CALML3	IL2RA
Description		calmodulin like 3	interleukin 2 receptor subunit alpha
Image
GO Annotations	Cellular Component	Extracellular Exosome	Plasma Membrane Interleukin-2 Receptor Complex External Side Of Plasma Membrane
	Molecular Function	Calcium Ion Binding Protein Binding Enzyme Regulator Activity	Interleukin-2 Receptor Activity Protein Binding Interleukin-2 Binding
	Biological Process	Regulation Of Catalytic Activity	Inflammatory Response To Antigenic Stimulus Regulation Of T Cell Tolerance Induction Apoptotic Process Activation-induced Cell Death Of T Cells Inflammatory Response Immune Response Cell Surface Receptor Signaling Pathway Notch Signaling Pathway Interleukin-2-mediated Signaling Pathway Positive Regulation Of Activated T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of T Cell Differentiation Regulation Of T Cell Homeostatic Proliferation Negative Regulation Of Inflammatory Response
Pathways			RAF/MAP kinase cascade RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs) Interleukin-2 signaling Interleukin receptor SHC signaling
Drugs			Denileukin diftitox Aldesleukin Basiliximab Daclizumab
Diseases
GWAS		Fasting insulin ( 34074324)	Allergic disease (asthma, hay fever or eczema) ( 29083406 29785011) Alopecia areata ( 20596022 25608926) Arthritis (juvenile idiopathic) ( 33106285) Asthma ( 31361310 31959851 30929738 34103634 32296059 31619474) Asthma (adult onset) ( 30929738) Asthma (bronchodilator response) ( 23508266) Asthma (childhood onset) ( 30929738) Asthma and hay fever ( 24388013) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 26482879) Autoimmune thyroid disease ( 32581359) Autoimmune thyroid diseases (Graves disease or Hashimoto's thyroiditis) ( 22922229) Autoimmune traits (pleiotropy) ( 30572963) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Crohn's disease ( 28067908 21102463) Diisocyanate-induced asthma ( 25918132) Eczema ( 31361310) Emotional dysregulation ( 27643478) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Epstein Barr virus nuclear antigen 1 IgG levels or multiple sclerosis ( 26819262) Graves' disease ( 22922229) Inflammatory biomarkers ( 22228203) Inflammatory bowel disease ( 23128233) Interleukin-2 receptor antagonist levels ( 27989323) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761) Liver fibrogenesis (alpha smooth muscle actin levels) ( 32953199) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494 27863252) Marginal zone lymphoma or multiple sclerosis ( 31407831) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 31604244 22190364 24076602 19525953 19525955 17660530 21833088 27386562 28445677) Neutrophil percentage of white cells ( 32888494) Pediatric autoimmune diseases ( 26301688) Plasma t-tau levels ( 28100725) Primary sclerosing cholangitis ( 23603763 27992413) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 3 peripheral neuropathy) ( 24554482) Rheumatoid arthritis ( 24449572 30423114 30572963 23143596 24390342 20453842) Rheumatoid arthritis (ACPA-positive) ( 23143596) Selective IgA deficiency ( 27723758) Soluble interleukin-2 receptor subunit alpha ( 26293465) Systemic lupus erythematosus ( 28714469) Type 1 diabetes ( 21829393 25751624 19430480 30572963 22293688 18978792) Vitiligo ( 20410501 27723757) White blood cell count ( 32888494)
Interacting Genes		10 interacting genes: BHLHE40 C11orf65 IL2RA IQCB1 IQCN ISOC2 MAPK4 MFHAS1 MYO10 TERF2IP	17 interacting genes: AKR1C3 ARHGAP12 CALML3 CD4 FGF12 FKBP4 GTPBP4 ICAM1 IL2 IL2RB JCAD KIN NFKB1 PFKP SNTA1 STAT3 STAT5B
Entrez ID		810	3559
HPRD ID		00244	00986
Ensembl ID		ENSG00000178363	ENSG00000134460
Uniprot IDs		P27482	P01589 Q5W005
PDB IDs		1GGZ	1ILM 1ILN 1Z92 2B5I 2ERJ 3IU3 3NFP 6VWU 6YIO
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?