ACTN4 and COL17A1

Number of citations of the paper that reports this interaction (PubMedID 11739652)
16

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, two hybrid)

		ACTN4	COL17A1
Description		actinin alpha 4	collagen type XVII alpha 1 chain
Image			No pdb structure
GO Annotations	Cellular Component	Stress Fiber Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Nuclear Body Z Disc Cell Junction Cortical Actin Cytoskeleton Platelet Alpha Granule Lumen Pseudopodium Protein-containing Complex Cell Projection Perinuclear Region Of Cytoplasm Extracellular Exosome Ribonucleoprotein Complex	Extracellular Region Collagen Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Hemidesmosome Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Nucleoside Binding Transcription Coactivator Activity RNA Binding Actin Binding Integrin Binding Calcium Ion Binding Protein Binding Nuclear Receptor Binding Nuclear Receptor Coactivator Activity Chromatin DNA Binding Protein Homodimerization Activity Retinoic Acid Receptor Binding Transmembrane Transporter Binding Actin Filament Binding	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Protein Transport Actin Cytoskeleton Organization Vesicle Transport Along Actin Filament Positive Regulation Of Cell Migration Positive Regulation Of Sodium:proton Antiporter Activity Tumor Necrosis Factor-mediated Signaling Pathway Peroxisome Proliferator Activated Receptor Signaling Pathway Regulation Of Apoptotic Process Positive Regulation Of Transcription, DNA-templated Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Cellular Component Movement Muscle Cell Development Negative Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of NIK/NF-kappaB Signaling Regulation Of Nucleic Acid-templated Transcription	Cell-matrix Adhesion Epidermis Development Extracellular Matrix Organization Hemidesmosome Assembly
Pathways		Platelet degranulation Nephrin family interactions	Collagen degradation Collagen biosynthesis and modifying enzymes Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Assembly of collagen fibrils and other multimeric structures Type I hemidesmosome assembly Collagen chain trimerization
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Fasting glucose ( 34074324) Heart rate ( 23583979) Immature fraction of reticulocytes ( 32888494) Logical memory (immediate recall) in mild cognitive impairment ( 29274321) Mean platelet volume ( 32888494) Retinal venular tortuosity ( 31597446) Waist circumference ( 28552196)	Cardiac hypertrophy ( 21348951)
Interacting Genes		55 interacting genes: ACTC1 ACTN3 ADORA2A ATP6V1B1 ATXN7 BMP7 C14orf119 CAMK2A CAMK2B CAMK2G CDKN2A COIL COL17A1 DDIAS ESR1 GSN HDAC7 HSPB1 INO80 ITGB1 KPNA2 LCMT2 LNX1 LRRC7 MAGI1 MAPK7 MEF2A MEOX2 MICALL2 MYOZ1 MYOZ2 NEB NOS2 NOS3 PDLIM1 POT1 PTGER4 PTPN11 PTPN6 RARA RPS27 SACS SERPINE1 SLC2A4 SLC9A3R2 SORBS2 STAT1 TJP1 TRIM23 TRIM3 TTN TXN UCHL5 USP6NL VDR	18 interacting genes: ACTN1 ACTN4 CLSTN1 CSTF2T CTNND1 DSP DST ITGA6 ITGB4 KRT18 LAD1 PLEC PLOD3 PNKP PPIL1 PPL UBQLN2 WHRN
Entrez ID		81	1308
HPRD ID		05222	00223
Ensembl ID		ENSG00000130402	ENSG00000065618
Uniprot IDs		A0A0S2Z3G9 F5GXS2 H7C144 O43707	Q9UMD9
PDB IDs		1WLX 1YDI 2R0O 6O31 6OA6
Enriched GO Terms of Interacting Partners?
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