REEP4 and ORMDL1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		REEP4	ORMDL1
Description		receptor accessory protein 4	ORMDL sphingolipid biosynthesis regulator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytoplasmic Microtubule Membrane Integral Component Of Membrane Endoplasmic Reticulum Tubular Network	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane SPOTS Complex
	Molecular Function	Protein Binding Microtubule Binding	Protein Binding
	Biological Process	Nuclear Envelope Organization Mitotic Nuclear Membrane Reassembly Cell Division Endoplasmic Reticulum Tubular Network Organization	Ceramide Metabolic Process Cellular Sphingolipid Homeostasis Negative Regulation Of Ceramide Biosynthetic Process
Pathways		Olfactory Signaling Pathway	Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Frailty index ( 34431594) Hypertriglyceridemia ( 23505323)	Bilirubin levels ( 20639394) Ferritin levels ( 25162662)
Interacting Genes		97 interacting genes: AGPAT4 BCL2L1 BET1 BIK BMP10 C14orf180 C1S C2CD2L C4orf3 CCL4L2 CLDND2 CMTM3 COMT CTSA CYB5B CYB5R3 CYP4F2 DCBLD2 DERL1 DGAT2L6 DNAJC30 ERG28 FAM241B FBXO7 FMO1 FUNDC2 GIMAP1 GYPB HSD3B7 HTATIP2 IFITM3 ITGAM LEMD1 LEMD3 LEPROTL1 LNPEP MAL2 MOSPD3 MS4A1 NCK2 ORMDL1 PEX16 PLP2 PMP22 PRAF2 RTP2 RTP4 SEC22B SELENOK SELENOM SERF1A SERF1B SERP1 SFT2D1 SFT2D2 SFXN2 SFXN3 SLC25A46 SLC30A8 SLC7A8 SMAGP SMIM1 SQLE STATH STX3 STX5 SYNJ2BP TIMM22 TMEM120B TMEM121 TMEM128 TMEM167B TMEM18 TMEM19 TMEM199 TMEM208 TMEM229B TMEM254 TMEM50A TMEM51 TMEM60 TMEM65 TMEM86A TMX2 TPRG1 TSNARE1 TSPAN2 TVP23B UBE2J1 UBIAD1 UNC50 VAMP1 VAMP4 VAPB VTI1B YIF1A YIPF4	37 interacting genes: APP AQP6 ARL13B ASGR2 COQ9 CPLX4 CREB3 CREB3L1 EBAG9 EBP EHHADH ERGIC3 GPR152 HSD17B11 KCNK4 LMNA LNX1 MFSD14B PCNX2 PGRMC2 REEP4 SAR1A SCN3B SLC10A1 SLC10A6 SLC18A1 SLC30A8 SLC35C2 STOM TLCD4 TMEM143 TMEM14B TMEM35A TMEM52B VMA21 ZDHHC15 ZFYVE27
Entrez ID		80346	94101
HPRD ID		09864	15092
Ensembl ID		ENSG00000168476	ENSG00000128699
Uniprot IDs		E5RGS2 Q9H6H4	Q9P0S3
PDB IDs
Enriched GO Terms of Interacting Partners?
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