SPG11 and PAK6

		SPG11	PAK6
Description		SPG11 vesicle trafficking associated, spatacsin	p21 (RAC1) activated kinase 6
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Cytoplasm Lysosomal Membrane Cytosol Plasma Membrane Axon Dendrite Cytoplasmic Vesicle Synapse	Fibrillar Center Nucleoplasm Cytoplasm Cytosol Cell Junction
	Molecular Function	Protein Binding	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Cadherin Binding Protein Serine Kinase Activity
	Biological Process	Chemical Synaptic Transmission Axo-dendritic Transport Synaptic Vesicle Transport Axon Extension Phagosome-lysosome Fusion Involved In Apoptotic Cell Clearance Walking Behavior	Regulation Of Transcription, DNA-templated Protein Phosphorylation Apoptotic Process Cytoskeleton Organization Learning Memory Locomotory Behavior Intracellular Signal Transduction Regulation Of MAPK Cascade Neuron Projection Arborization Neuron Projection Extension
Pathways			Activation of RAC1 CDC42 GTPase cycle RAC1 GTPase cycle RHOD GTPase cycle RHOH GTPase cycle RHOV GTPase cycle
Drugs			Fostamatinib
Diseases
GWAS		Anti-Toxoplasma gondii IgG seropositivity ( 30610941) Apolipoprotein A1 levels ( 32203549) HDL cholesterol levels ( 32203549)	Obesity-related traits ( 23251661) Schizophrenia ( 25056061 29483656) Weight gain in amisulpride-treated first-episode psychosis ( 32126890)
Interacting Genes		2 interacting genes: PAK6 SERTAD3	28 interacting genes: APP AR CACNA1H CDC42 CDIN1 CDK1 DAPK1 DLL4 ESR1 FBXO7 GJD2 HSF2BP KNL1 LIMK1 LRRK1 MAPK14 MDM2 NEK6 PTPRD RAC1 RHOJ RHOV SEMA3B SNX2 SP3 SPG11 SUMO2 TPD52L1
Entrez ID		80208	56924
HPRD ID		07963	06426
Ensembl ID		ENSG00000104133	ENSG00000137843
Uniprot IDs		Q96JI7	A0A024R9Q4 Q9NQU5
PDB IDs			2C30 2ODB 4KS7 4KS8 6QDR 6QDS
Enriched GO Terms of Interacting Partners?
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