ZBTB3 and SUPT5H

Number of citations of the paper that reports this interaction (PubMedID 20211142)
361

Data Source:
BioGRID (two hybrid)

		ZBTB3	SUPT5H
Description		zinc finger and BTB domain containing 3	SPT5 homolog, DSIF elongation factor subunit
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus	Nucleus Nucleoplasm DSIF Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding Metal Ion Binding	Chromatin Binding RNA Binding MRNA Binding Protein Binding Enzyme Binding Protein Heterodimerization Activity
	Biological Process	Regulation Of Transcription By RNA Polymerase II	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription By RNA Polymerase II Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Macroautophagy Negative Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of MRNA Polyadenylation
Pathways			Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex RNA Pol II CTD phosphorylation and interaction with CE during HIV infection Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA polymerase II transcribes snRNA genes mRNA Capping RNA Polymerase II Transcription Elongation RNA Pol II CTD phosphorylation and interaction with CE
Drugs
Diseases
GWAS		Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)	Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		24 interacting genes: ANKRD2 AP1M1 BIN1 EIF5B FOXM1 GATA4 GTF2A1L IKBKG IRF6 JADE2 LEF1 MYO15B NR3C1 PKNOX1 PPARG PROX1 SKIL SMAD3 SMYD1 SSX3 SUPT5H THRA ZMYM2 ZNF556	45 interacting genes: C9orf78 CCNH CCNT1 CCNT2 CDK7 CDK9 CEP55 CSNK2A1 DBN1 DCAF6 FHL3 GOLGA2 GTF3C1 H2AX HSPB1 HTATSF1 IK IKBKG LMAN2 MAD1L1 MAML3 MNAT1 PCBD1 PHYHIP PIN1 PNO1 POLR2A PPIA PPP2R2D PRMT1 PRMT5 SAP30BP SIK1 SNX4 SSBP3 SUMO2 SUPT4H1 TERF1 TEX11 TLE5 XRCC5 ZBTB3 ZFYVE9 ZNF496 ZNF512B
Entrez ID		79842	6829
HPRD ID		15693	03655
Ensembl ID		ENSG00000185670	ENSG00000196235
Uniprot IDs			O00267
PDB IDs			2DO3 2E6Z 2E70 3H7H 4L1U 5OHO 5OHQ 5OIK 5U98 6EQY 6ER0 6GMH 6GML 6TED
Enriched GO Terms of Interacting Partners?
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