FBXO31 and GHR

Number of citations of the paper that reports this interaction (PubMedID 25505247)
12

Data Source:
BioGRID (unspecified method)

		FBXO31	GHR
Description		F-box protein 31	growth hormone receptor
Image
GO Annotations	Cellular Component	Centrosome Cytosol SCF Ubiquitin Ligase Complex Neuronal Cell Body	Extracellular Region Extracellular Space Nucleus Mitochondrion Cytosol Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Integral Component Of Membrane Cytoplasmic Ribonucleoprotein Granule Neuronal Cell Body Receptor Complex Growth Hormone Receptor Complex
	Molecular Function	Protein Binding Cyclin Binding	Cytokine Receptor Activity Growth Hormone Receptor Activity Protein Binding Peptide Hormone Binding Growth Factor Binding Protein Kinase Binding Protein Phosphatase Binding Cytokine Binding SH2 Domain Binding Identical Protein Binding Protein Homodimerization Activity Proline-rich Region Binding
	Biological Process	Cellular Response To DNA Damage Stimulus Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process Mitotic G1 DNA Damage Checkpoint Signaling Positive Regulation Of Dendrite Morphogenesis Positive Regulation Of Neuron Migration	Endocytosis Receptor Signaling Pathway Via JAK-STAT Hormone-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Taurine Metabolic Process Response To Food Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Regulation Of Multicellular Organism Growth Positive Regulation Of Multicellular Organism Growth Hormone Metabolic Process Positive Regulation Of Tyrosine Phosphorylation Of STAT Protein Activation Of Janus Kinase Activity Response To Morphine Positive Regulation Of MAP Kinase Activity Positive Regulation Of Cell Differentiation Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Insulin-like Growth Factor Receptor Signaling Pathway Positive Regulation Of Peptidyl-tyrosine Phosphorylation Response To Glucocorticoid Cartilage Development Involved In Endochondral Bone Morphogenesis Growth Hormone Receptor Signaling Pathway Response To Interleukin-1 Negative Regulation Of Neuron Death
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Prolactin receptor signaling Growth hormone receptor signaling Growth hormone receptor signaling
Drugs			Somatotropin Pegvisomant Somatrem Somapacitan
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Experiencing mood swings ( 29500382) Feeling nervous ( 29500382) Major depressive disorder ( 22472876) Neurociticism ( 29500382) Neuroticism ( 29255261)	Blood protein levels ( 30072576 29875488) Familial squamous cell lung carcinoma ( 29924316) Heel bone mineral density ( 30598549) Height ( 28552196 25429064 31562340) Hip circumference adjusted for BMI ( 34021172) Iron status biomarkers ( 19084217) Menarche (age at onset) ( 25231870) Plasma renin activity levels ( 29650764) Response to taxane treatment (docetaxel) ( 23006423) Systemic lupus erythematosus ( 18204098)
Interacting Genes		5 interacting genes: AKT1 CCND1 CDT1 GHR MDM2	45 interacting genes: AP2A1 BTRC CISH CLCC1 CUL1 CUL5 DUSP7 ELOB ELOC FBXO31 GH1 GH2 GRB10 GRB2 IRS1 JAK1 JAK2 NCOA6 NEDD8 PIK3R1 PIK3R2 PLCG1 PTPN1 PTPN11 PTPN13 PTPN2 PTPN3 PTPN6 PTPN9 PTPRB PTPRH RBX1 RNF7 SGTA SHC1 SKP1 SOCS1 SOCS2 SOCS3 SRPK2 STAT3 STAT5A STAT5B STUB1 TYK2
Entrez ID		79791	2690
HPRD ID		10954	02971
Ensembl ID		ENSG00000103264	ENSG00000112964
Uniprot IDs		A0A0C4DGU8 Q5XUX0	A0A087X0H5 A0A087X162 P10912
PDB IDs		5VZT 5VZU	1A22 1AXI 1HWG 1HWH 1KF9 2AEW 3HHR 5OEK 5OHD
Enriched GO Terms of Interacting Partners?
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