CERS4 and TMEM72

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		CERS4	TMEM72
Description		ceramide synthase 4	transmembrane protein 72
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane	Integral Component Of Membrane
	Molecular Function	DNA Binding Protein Binding N-acyltransferase Activity Sphingosine N-acyltransferase Activity	Protein Binding
	Biological Process	Sphingolipid Biosynthetic Process Ceramide Biosynthetic Process
Pathways		Sphingolipid de novo biosynthesis
Drugs
Diseases
GWAS		Macular telangiectasia type 2 ( 33654266) Mean reticulocyte volume ( 32888494) Metabolite levels ( 31628463) Red cell distribution width ( 32888494) Refractive error ( 32231278) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingolipid levels ( 26068415) Sphingomyelin levels ( 31551469) Thyroid stimulating hormone levels ( 30367059 32769997) Very long-chain saturated fatty acid levels (fatty acid 24:0) ( 25378659)	Body mass index ( 25760438) Diastolic blood pressure ( 27841878) Moderate or severe prolonged lymphopenia in dimethyl fumarate-treated relapsing-remitting multiple sclerosis ( 31749835) Refractive error ( 32231278) Selective IgA deficiency ( 27723758)
Interacting Genes		47 interacting genes: - C1QL4 CCL4L2 CLEC1A COL4A5 CTXN3 CXCL16 CYB5R3 EMD FATE1 FCER1G FXYD6 FXYD6-FXYD2 GPR151 IER3IP1 IGFBP5 ITGAM JAGN1 LHFPL5 MS4A1 NAT8 NEU1 PLP2 PNLIPRP1 PTPN9 SCAMP5 SCD SERF1A SERF1B SERP2 SLC13A4 SLC29A2 SLC35A1 SLC35F6 SLC7A1 SMIM11 STX7 STX8 TEX264 TMEM119 TMEM176A TMEM254 TMEM72 TOMM6 TSPO2 UPK1B VAMP2	10 interacting genes: BCL2L13 CERS4 FAM209A FXYD6 GJA8 LENEP MS4A1 PIGY SLC35A5 TMEM237
Entrez ID		79603	643236
HPRD ID		13962
Ensembl ID		ENSG00000090661	ENSG00000187783
Uniprot IDs		Q53HF9 Q9HA82	A0PK05
PDB IDs
Enriched GO Terms of Interacting Partners?
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