NELFE and NELFB

Number of citations of the paper that reports this interaction (PubMedID 10199401)
359

Data Source:
HPRD (two hybrid, in vivo, in vitro)

		NELFE	NELFB
Description		negative elongation factor complex member E	negative elongation factor complex member B
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Plasma Membrane Nuclear Body NELF Complex	Nucleoplasm Cytoplasm NELF Complex
	Molecular Function	Chromatin Binding RNA Binding Protein Binding	RNA Binding Protein Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Histone H3-K4 Methylation Positive Regulation Of ERK1 And ERK2 Cascade Negative Regulation Of MRNA Polyadenylation	Cell Population Proliferation Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Stem Cell Differentiation Negative Regulation Of Stem Cell Differentiation
Pathways		Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation	Formation of RNA Pol II elongation complex Formation of the Early Elongation Complex Formation of HIV elongation complex in the absence of HIV Tat Formation of the HIV-1 Early Elongation Complex Formation of HIV-1 elongation complex containing HIV-1 Tat Formation of HIV-1 elongation complex containing HIV-1 Tat Pausing and recovery of Tat-mediated HIV elongation Abortive elongation of HIV-1 transcript in the absence of Tat Tat-mediated HIV elongation arrest and recovery Tat-mediated elongation of the HIV-1 transcript HIV elongation arrest and recovery Pausing and recovery of HIV elongation RNA Polymerase II Pre-transcription Events TP53 Regulates Transcription of DNA Repair Genes RNA Polymerase II Transcription Elongation NTRK3 as a dependence receptor
Drugs
Diseases
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Blood protein levels ( 28240269) Body shape index ( 34021172) Coronary artery disease ( 29212778) Disease progression in age-related macular degeneration ( 29346644) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Ulcerative colitis ( 28067908) vWF levels ( 30586737) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		10 interacting genes: CACTIN CCDC57 MTUS2 NCOR1 NELFB SRPK1 SRPK2 TNKS TRIM27 VAMP3	17 interacting genes: BRCA1 CEBPE DENR ESR1 EXOSC2 FOS HSPA9 JUN KHDRBS3 MAPK6 MGST1 NELFE NTRK3 RAD51 TPRX1 TUBB4B WDR5
Entrez ID		7936	25920
HPRD ID		01096	10845
Ensembl ID		ENSG00000204356	ENSG00000188986
Uniprot IDs		A0A1U9X830 P18615	Q8WX92
PDB IDs		1X5P 2BZ2 2JX2 5OOB 6GML	6GML
Enriched GO Terms of Interacting Partners?
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