THTPA and DPAGT1

		THTPA	DPAGT1
Description		thiamine triphosphatase	dolichyl-phosphate N-acetylglucosaminephosphotransferase 1
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GO Annotations	Cellular Component	Cytosol	Endoplasmic Reticulum Membrane Membrane Integral Component Of Membrane Integral Component Of Endoplasmic Reticulum Membrane Intracellular Membrane-bounded Organelle
	Molecular Function	Magnesium Ion Binding Protein Binding Hydrolase Activity Thiamin-triphosphatase Activity	UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase Activity UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase Activity Protein Binding Phospho-N-acetylmuramoyl-pentapeptide-transferase Activity Glycosyltransferase Activity Identical Protein Binding Metal Ion Binding
	Biological Process	Generation Of Precursor Metabolites And Energy Thiamine Metabolic Process Dephosphorylation Thiamine Diphosphate Metabolic Process	UDP-N-acetylglucosamine Metabolic Process Protein N-linked Glycosylation Dolichol-linked Oligosaccharide Biosynthetic Process Dolichyl Diphosphate Biosynthetic Process Dolichol Metabolic Process
Pathways		Vitamin B1 (thiamin) metabolism	Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein Defective DPAGT1 causes DPAGT1-CDG (CDG-1j) and CMSTA2
Drugs
Diseases
GWAS			Estimated glomerular filtration rate ( 31152163) Lymphocyte percentage of white cells ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)
Interacting Genes		8 interacting genes: DPAGT1 GCDH HEY1 METTL17 OR4K5 PDE6B RNASE7 TLX3	7 interacting genes: CXCR5 ETS1 LSM8 MFSD3 THTPA TUBE1 WDR5
Entrez ID		79178	1798
HPRD ID		15505	01879
Ensembl ID		ENSG00000259431	ENSG00000172269
Uniprot IDs		G3V5Q5 Q9BU02	A0A024R3H8 Q9H3H5
PDB IDs		3BHD 3TVL	5LEV 5O5E 6BW5 6BW6 6FM9 6FWZ 6JQ3
Enriched GO Terms of Interacting Partners?
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