KCTD15 and NOXA1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		KCTD15	NOXA1
Description		potassium channel tetramerization domain containing 15	NADPH oxidase activator 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component		Cytosol NADPH Oxidase Complex
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Superoxide-generating NADPH Oxidase Activator Activity SH3 Domain Binding Enzyme Binding Small GTPase Binding
	Biological Process	Protein Homooligomerization	Superoxide Metabolic Process Regulation Of Hydrogen Peroxide Metabolic Process Superoxide Anion Generation Regulation Of Catalytic Activity Regulation Of Respiratory Burst
Pathways		Negative regulation of activity of TFAP2 (AP-2) family transcription factors	RHO GTPases Activate NADPH Oxidases CDC42 GTPase cycle RAC1 GTPase cycle RAC3 GTPase cycle WNT5:FZD7-mediated leishmania damping
Drugs
Diseases
GWAS		BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 19079260 19079261 28892062 25673413 20935630 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Dental caries (decayed and filled deciduous teeth) ( 31533690) Dental caries (decayed and filled deciduous tooth surfaces) ( 31533690) Disease progression in age-related macular degeneration ( 29346644) Major depressive disorder ( 23377640) Obesity-related traits ( 23251661) Response to antidepressants (symptom remission) ( 29160301) Response to SSRI (symptom remission) ( 29160301) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Weight ( 19079260)	Response to fenofibrate (total cholesterol levels) ( 27002377)
Interacting Genes		15 interacting genes: ATXN1 CYSRT1 ENSA KCTD1 KCTD21 NBPF19 NOTCH2NLA NOXA1 NTAQ1 REN TFAP2A TRIM27 TRIM55 TRIM63 WIPI1	57 interacting genes: ANKRD55 C19orf54 C9orf24 CACNA1A CEP70 CFP CRYBA1 CTDSP1 CYSRT1 DCLRE1B DDAH2 DUSP4 EP300 FAT1 GATAD2B IL16 KCTD15 KRTAP13-1 KRTAP15-1 KRTAP19-4 KRTAP19-7 KRTAP8-1 LASP1 LMO2 MAPK1 MAPK11 METTL27 MORN3 MYLIP NAA10 NADSYN1 NCF1 NDUFAB1 NOX1 NOXO1 PFDN5 PLA2G10 PRKACA PRKCA PRKCG QARS1 RAC1 RAC2 REL RIMBP3 RIMBP3C SMUG1 TCF19 TCF4 TGS1 TRAF2 TRIM23 UBAP2 WDR83 ZC2HC1C ZNF474 ZNF620
Entrez ID		79047	10811
HPRD ID		13765	17644
Ensembl ID		ENSG00000153885	ENSG00000188747
Uniprot IDs		Q96SI1	Q86UR1
PDB IDs
Enriched GO Terms of Interacting Partners?
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