SLBP and PTGER4

Number of citations of the paper that reports this interaction (PubMedID 28298427)
23

Data Source:
BioGRID (two hybrid)

		SLBP	PTGER4
Description		stem-loop binding protein	prostaglandin E receptor 4
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Histone Pre-mRNA 3'end Processing Complex Ribonucleoprotein Complex	Plasma Membrane Integral Component Of Membrane
	Molecular Function	RNA Binding MRNA Binding Protein Binding Identical Protein Binding Histone Pre-mRNA Stem-loop Binding Histone Pre-mRNA DCP Binding	Prostaglandin E Receptor Activity Protein Binding
	Biological Process	MRNA 3'-end Processing By Stem-loop Binding And Cleavage MRNA Transport	Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Inflammatory Response Immune Response Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration JNK Cascade Response To Mechanical Stimulus Regulation Of Ossification Response To Lipopolysaccharide Negative Regulation Of Integrin Activation T-helper Cell Differentiation Negative Regulation Of Inflammatory Response Positive Regulation Of Inflammatory Response Regulation Of Stress Fiber Assembly Bone Development ERK1 And ERK2 Cascade Cellular Response To Mechanical Stimulus Cellular Response To Prostaglandin E Stimulus Negative Regulation Of Eosinophil Extravasation
Pathways		Transport of the SLBP Dependant Mature mRNA RNA Polymerase II Transcription Termination SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs	Prostanoid ligand receptors G alpha (s) signalling events ADORA2B mediated anti-inflammatory cytokines production
Drugs			Dinoprostone Misoprostol Limaprost Castor oil Grapiprant
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Hip circumference adjusted for BMI ( 34021172 25673412) Hip index ( 34021172) Hip minimal joint space width ( 27701424) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean reticulocyte volume ( 32888494) Metabolite levels ( 23823483) Subcortical volume (MOSTest) ( 32665545) Urinary bladder cancer ( 20348956)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Ankylosing spondylitis ( 23749187 21743469) Aspartate aminotransferase levels ( 33547301) Blood urea nitrogen levels ( 31152163) Colorectal cancer or advanced adenoma ( 30510241) Crohn's disease ( 18587394 17684544 22936669 22412388 26278503 21102463) Gastric cancer ( 22037551 26098866) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 19525953 21833088 22570697 28445677) Pediatric autoimmune diseases ( 26301688) Red blood cell count ( 32888494) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Serum urea levels ( 30808845) Type 1 diabetes ( 34127860) Ulcerative colitis ( 21297633)
Interacting Genes		10 interacting genes: CDK4 CDK6 DCAF11 ERI1 FBN1 LSM10 NSD2 PTGER4 USP8 ZNF473	43 interacting genes: ACTN4 ACY3 ANAPC7 ATXN10 BIN1 BNIP1 CDPF1 CFAP298 CRADD CRY2 CTNND2 DPF1 DST EHMT2 FEM1A GJC2 HMOX1 HMOX2 HOPX KLC1 NISCH NUBP2 NUP153 PDLIM1 PMPCB PPP1R3F PRDX1 PSMC1 PTPRA RNF220 RTF2 SLBP SLC39A8 SND1 SPP1 ST13 SUGT1 TCHH TMEM161A TRAP1 VSTM2A WDR19 ZNF337
Entrez ID		7884	5734
HPRD ID		03884	03350
Ensembl ID		ENSG00000163950	ENSG00000171522
Uniprot IDs		B3KSC5 B3KST9 B4DUW7 E7EUV9 Q14493 Q53XR2	A0PJF5 P35408
PDB IDs		2KJM 4L8R 4QOZ	5YHL 5YWY 7D7M
Enriched GO Terms of Interacting Partners?
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