CACNB2 and NEBL

		CACNB2	NEBL
Description		calcium voltage-gated channel auxiliary subunit beta 2	nebulette
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Calcium Channel Complex Photoreceptor Ribbon Synapse Presynapse L-type Voltage-gated Calcium Channel Complex	Stress Fiber Z Disc I Band Extracellular Exosome
	Molecular Function	Voltage-gated Calcium Channel Activity Calcium Channel Activity Protein Binding High Voltage-gated Calcium Channel Activity Actin Filament Binding Voltage-gated Calcium Channel Activity Involved In Cardiac Muscle Cell Action Potential Voltage-gated Calcium Channel Activity Involved In AV Node Cell Action Potential Voltage-gated Calcium Channel Activity Involved In Positive Regulation Of Presynaptic Cytosolic Calcium Levels	Protein Binding Tropomyosin Binding Cytoskeletal Protein Binding Structural Constituent Of Muscle Filamin Binding Actin Filament Binding
	Biological Process	Chemical Synaptic Transmission Neuromuscular Junction Development Visual Perception Positive Regulation Of Calcium Ion Transport Calcium Ion Import Calcium Ion Transmembrane Transport Protein Localization To Plasma Membrane Membrane Depolarization During AV Node Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Membrane Depolarization During Atrial Cardiac Muscle Cell Action Potential Induction Of Synaptic Vesicle Exocytosis By Positive Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Regulation Of Voltage-gated Calcium Channel Activity Positive Regulation Of High Voltage-gated Calcium Channel Activity Positive Regulation Of Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel	Cardiac Muscle Thin Filament Assembly
Pathways		Presynaptic depolarization and calcium channel opening Adrenaline,noradrenaline inhibits insulin secretion NCAM1 interactions Regulation of insulin secretion Regulation of insulin secretion Phase 0 - rapid depolarisation Phase 2 - plateau phase Sensory processing of sound by inner hair cells of the cochlea
Drugs		Ergocalciferol Enflurane Ranolazine Phenytoin Isradipine Topiramate Nimodipine Nisoldipine Spironolactone Nicardipine Magnesium sulfate Levomenthol Felodipine Nitrendipine Miconazole Nifedipine Amiodarone Mibefradil Dronedarone Nilvadipine Trimebutine Benidipine Cilnidipine Lacidipine Manidipine Butamben Bioallethrin Bioallethrin Fish oil
Diseases
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Antisaccade task score ( 31596458) Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood pressure ( 21909110) Body mass index ( 28892062) Brain volume in infants (grey matter) ( 28763065) Cadmium levels ( 26025379) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Diastolic blood pressure ( 19430479 27841878 21909115 28739976 27618452) Diastolic blood pressure (cigarette smoking interaction) ( 29455858) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diverticular disease ( 30177863) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hypertension ( 31879980 19430479 21909115) LDL cholesterol levels ( 32203549) Mean arterial pressure ( 27618448) Mean arterial pressure x alcohol consumption interaction (2df test) ( 29912962) Medication use (agents acting on the renin-angiotensin system) ( 31015401) Medication use (beta blocking agents) ( 31015401) Medication use (calcium channel blockers) ( 31015401) Medication use (diuretics) ( 31015401) Metabolite levels (HVA/MHPG ratio) ( 23319000) Nicotine dependence symptom count ( 25555482) Obesity-related traits ( 23251661) Primary tooth development (number of teeth) ( 23704328) Primary tooth development (time to first tooth eruption) ( 23704328) Protein quantitative trait loci ( 18464913) Pulse pressure ( 30578418) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Quantitative traits ( 19197348) Response to antiepileptic drugs in genetic generalized epilepsy ( 32308125) Schizophrenia ( 28991256 25056061 29483656 30285260 23974872) Small vessel stroke ( 26732560) Systolic blood pressure ( 28135244 19430479 27841878 21909115 28739976 27618452 30578418) Systolic blood pressure (cigarette smoking interaction) ( 29455858) Systolic blood pressure x alcohol consumption (light vs heavy) interaction (2df test) ( 29912962) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) White matter hyperintensity volume ( 33293549)	Age-related cognitive decline (global cognition) (slope of z-scores) ( 30954325) Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Atrial fibrillation ( 28416822) Coronary artery aneurysm in Kawasaki disease ( 27171184) Gastroesophageal reflux disease ( 34187846) Heel bone mineral density ( 30598549) Liver injury in combined anti-retroviral and anti-tuberculosis drug-treated HIV with tuberculosis ( 28388302) Metabolite levels ( 23823483) Ovarian cancer ( 23535730) Photic sneeze reflex ( 27182965) Plasma anti-thyroglobulin and anti-thyroid peroxidase levels (bivariate analysis) ( 29678681) Plasma anti-thyroid peroxidase levels ( 29678681) Pulse pressure ( 27841878) Refractive error ( 32231278) Response to TNF inhibitor in rheumatoid arthritis (change in swollen 28-joint count) ( 30166627) Sporadic pituitary adenoma ( 26029870) Triglyceride levels x SSRI defined daily dose interaction in schizophrenia or bipolar disorder ( 33824429) Urate levels in lean individuals ( 25811787) Vertical cup-disc ratio (adjusted for vertical disc diameter) ( 31959993) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) Waist circumference ( 28552196) Walking pace ( 33128006)
Interacting Genes		13 interacting genes: C10orf67 CTBP2 GPR85 HEXIM2 MSRB2 NEBL NRP1 PDIA3 PRKACA PRMT5 PTER REM1 TMEM174	37 interacting genes: ACAP1 ACTB ACTN1 ACTN3 CACNB2 CCDC125 CCDC136 CEP70 FAM9B GMCL1 GOLGA2 GOLGA6A HOMER3 KIFC3 LZTS2 MAD1L1 MIPOL1 MYPN NRP1 NUTM1 PIBF1 PIK3R3 PRKAB2 PRRG4 QARS1 SPAG5 TRAF1 TRAF2 TRIM27 TRIM55 TRIM63 VCL XIRP1 XIRP2 ZDHHC17 ZGPAT ZYX
Entrez ID		783	10529
HPRD ID		02473	10403
Ensembl ID		ENSG00000165995	ENSG00000078114
Uniprot IDs		A0A494C0B2 A0A494C184 Q08289 Q59H42 Q5VVH1	O76041 Q59FZ8
PDB IDs			4F14
Enriched GO Terms of Interacting Partners?
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