DAP3 and AHR

Number of citations of the paper that reports this interaction (PubMedID 10903152)
3

Data Source:
HPRD (in vitro)

		DAP3	AHR
Description		death associated protein 3	aryl hydrocarbon receptor
Image
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Small Ribosomal Subunit	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Protein-containing Complex Aryl Hydrocarbon Receptor Complex Cytosolic Aryl Hydrocarbon Receptor Complex
	Molecular Function	RNA Binding Structural Constituent Of Ribosome Protein Binding GTP Binding	Transcription Cis-regulatory Region Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Cis-regulatory Region Sequence-specific DNA Binding TFIID-class Transcription Factor Complex Binding Transcription Coactivator Binding DNA Binding DNA-binding Transcription Factor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding TBP-class Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity Hsp90 Protein Binding E-box Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Apoptotic Signaling Pathway	Blood Vessel Development Regulation Of Adaptive Immune Response Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Xenobiotic Metabolic Process Apoptotic Process Cell Cycle Response To Xenobiotic Stimulus Response To Toxic Substance Regulation Of Gene Expression CAMP-mediated Signaling Intracellular Receptor Signaling Pathway Regulation Of B Cell Proliferation Circadian Regulation Of Gene Expression Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To CAMP Cellular Response To Forskolin Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine
Pathways		Mitochondrial translation initiation Mitochondrial translation elongation Mitochondrial translation elongation Mitochondrial translation termination	PPARA activates gene expression Phase I - Functionalization of compounds Endogenous sterols Xenobiotics Aryl hydrocarbon receptor signalling
Drugs			Omeprazole Mexiletine Nimodipine Flutamide Atorvastatin Leflunomide Ginseng Indirubin-3'-monoxime Resveratrol Quercetin beta-Naphthoflavone Emodin 1-[(4S)-4-amino-5-(1,3-benzothiazol-2-yl)-5-oxopentyl]guanidine Diosmin Indigotindisulfonic acid Kynurenic Acid Epigallocatechin gallate Cantharidin Indirubin
Diseases
GWAS		Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Bitter beverage consumption ( 31046077) Bitter non-alcoholic beverage consumption ( 31046077) Blood metabolite levels ( 24816252) Caffeine consumption ( 21490707) Caffeine consumption from coffee ( 33287642) Caffeine consumption from coffee or tea ( 33287642) Caffeine consumption from tea ( 33287642) Caffeine metabolism (plasma 1,3,7-trimethylxanthine (caffeine) level) ( 27702941) Caffeine metabolism (plasma 1,7-dimethylxanthine (paraxanthine) to 1,3,7-trimethylxanthine (caffeine) ratio) ( 27702941) Coffee consumption ( 31345160 21357676 31959922 29367735 31046077 25288136) Coffee consumption (cups per day) ( 31837886 25288136) Cutaneous malignant melanoma ( 32341527) Cutaneous squamous cell carcinoma ( 27424798 32041948) Estimated glomerular filtration rate ( 31152163) HDL cholesterol levels ( 32203549) Inflammatory bowel disease ( 26192919) Lung cancer in ever smokers ( 28604730) Metabolic traits ( 21886157) Microalbuminuria ( 31511532) Plasma kynurenine levels in major depressive disorder ( 29317604) Rosacea symptom severity ( 29771307) Severe influenza A (H1N1) infection ( 26379185) Sweet beverage consumption ( 31046077) Tea consumption ( 31046077) Triglyceride levels ( 32203549) Ulcerative colitis ( 26192919) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 30910378 31511532) Urinary potassium excretion ( 31409800) Urinary sodium excretion ( 31409800)
Interacting Genes		14 interacting genes: AHR AR ESR1 ESR2 FADD HIF1A HSP90AA1 NR3C1 PGR PPARA PTEN THRA TNFRSF10A TNFRSF25	36 interacting genes: AIP AR ARNT ARNT2 ARNTL BRCA1 CCNT1 CUL4B DAP3 EP300 ESR1 GSDME GTF2F1 GTF2F2 HSP90AA1 IVNS1ABP NCOA1 NCOA2 NCOA7 NCOR2 NEDD8 NR2F1 NRIP1 PTGES3 RB1 RELA SMARCA4 SP1 STUB1 TAF4 TAF6 TAF7 TAF9 TBL3 TBP XPO1
Entrez ID		7818	196
HPRD ID		03646	02596
Ensembl ID		ENSG00000132676	ENSG00000106546
Uniprot IDs		P51398	A0A024R9Z8 P35869
PDB IDs		3J9M 6NU2 6NU3 6RW4 6RW5 6VLZ 6VMI 6ZM5 6ZM6 6ZS9 6ZSA 6ZSB 6ZSC 6ZSD 6ZSE 6ZSG 7A5F 7A5G 7A5I 7A5K	5NJ8
Enriched GO Terms of Interacting Partners?
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