PTTG1IP and ATP6AP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		PTTG1IP	ATP6AP2
Description		PTTG1 interacting protein	ATPase H+ transporting accessory protein 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Membrane Integral Component Of Membrane Extracellular Exosome	Autophagosome Membrane Lysosome Lysosomal Membrane Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Endosome Membrane Integral Component Of Membrane Apical Plasma Membrane Vacuolar Proton-transporting V-type ATPase Complex Axon Dendritic Spine Membrane Cell Body Postsynaptic Membrane Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	P53 Binding Molecular_function Protein Binding	Protein Binding Signaling Receptor Activity
	Biological Process	Protein Import Into Nucleus Positive Regulation Of Protein Ubiquitination Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Positive Regulation Of Cellular Protein Catabolic Process	Angiotensin Maturation Lysosomal Lumen Acidification Central Nervous System Maturation Rostrocaudal Neural Tube Patterning Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Transforming Growth Factor Beta1 Production Regulation Of MAPK Cascade Eye Pigmentation Head Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways			Metabolism of Angiotensinogen to Angiotensins Neutrophil degranulation
Drugs
Diseases
GWAS		Ankylosing spondylitis ( 30946743) Apolipoprotein A1 levels ( 32203549) Delirium ( 29631748) Gamma glutamyl transferase levels ( 29403010) HDL cholesterol ( 30275531) HDL cholesterol levels ( 32203549 30698716) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) High density lipoprotein cholesterol levels ( 29403010 33339817) Liver enzyme levels (alanine transaminase) ( 33972514) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Red cell distribution width ( 32888494 28957414)	Metabolite levels ( 23823483)
Interacting Genes		13 interacting genes: AIRE AMIGO1 ATP6AP2 CLEC7A LDLRAD1 PTTG1 RAB4A RUNX1 SGCB SLC22A23 TMEM106C TMPRSS2 TNFSF14	21 interacting genes: ADRA1A AGT BBS1 CD72 CREB3 GLP1R HTR2C NKG7 NSG1 PMP22 PTTG1IP REN RPGR SEC22A TIMMDC1 TMEM203 TMEM97 UPK2 VAMP5 VKORC1 ZBTB16
Entrez ID		754	10159
HPRD ID		04807	06454
Ensembl ID		ENSG00000183255	ENSG00000182220
Uniprot IDs		B4DPZ0 P53801	O75787
PDB IDs			3LBS 3LC8 6WLW 6WM2 6WM3 6WM4
Enriched GO Terms of Interacting Partners?
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