YWHAZ and PTPN13

Number of citations of the paper that reports this interaction (PubMedID 7536343)
108

Data Source:
HPRD (in vivo, two hybrid)

		YWHAZ	PTPN13
Description		tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta	protein tyrosine phosphatase non-receptor type 13
Image
GO Annotations	Cellular Component	Extracellular Space Nucleus Nucleoplasm Cytoplasm Cytosol Focal Adhesion Vesicle Melanosome Extracellular Exosome Blood Microparticle Hippocampal Mossy Fiber To CA3 Synapse Glutamatergic Synapse	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol Cytoskeleton Plasma Membrane Lamellipodium Neuron Projection Cell Body Extracellular Exosome
	Molecular Function	RNA Binding Protein Binding Protein Kinase Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding Identical Protein Binding Transmembrane Transporter Binding Cadherin Binding DNA-binding Transcription Factor Binding	Protein Tyrosine Phosphatase Activity Protein Binding Phosphatidylinositol 3-kinase Regulatory Subunit Binding
	Biological Process	Angiogenesis Respiratory System Process Protein Phosphorylation Protein Targeting Signal Transduction Synaptic Target Recognition Lung Development Cellular Protein Localization Tube Formation Negative Regulation Of Apoptotic Process Establishment Of Golgi Localization ERK1 And ERK2 Cascade Regulation Of ERK1 And ERK2 Cascade Regulation Of Synapse Maturation Golgi Reassembly	Negative Regulation Of Protein Phosphorylation Protein Dephosphorylation Regulation Of Phosphatidylinositol 3-kinase Signaling Peptidyl-tyrosine Dephosphorylation
Pathways		Activation of BAD and translocation to mitochondria Translocation of SLC2A4 (GLUT4) to the plasma membrane Deactivation of the beta-catenin transactivating complex Rap1 signalling GP1b-IX-V activation signalling KSRP (KHSRP) binds and destabilizes mRNA Interleukin-3, Interleukin-5 and GM-CSF signaling RHO GTPases activate PKNs TP53 Regulates Metabolic Genes Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex NOTCH4 Activation and Transmission of Signal to the Nucleus Negative regulation of NOTCH4 signaling Regulation of localization of FOXO transcription factors	Synthesis of PIPs at the plasma membrane Interleukin-37 signaling RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle
Drugs		Phenethyl Isothiocyanate
Diseases
GWAS		Adventurousness ( 30643258) Attention deficit hyperactivity disorder and conduct disorder ( 18951430) Body mass index ( 25673413) Chronotype ( 30696823) Cognitive decline rate in late mild cognitive impairment ( 26252872) General risk tolerance (MTAG) ( 30643258) High light scatter reticulocyte count ( 32888494) Interleukin-10 levels ( 22205395)	Eyebrow thickness ( 26926045) Hemoglobin levels ( 32327693) Kidney disease (end stage renal disease vs non-end stage renal disease) in type 1 diabetes ( 27647854) Kidney disease (end stage renal disease vs normoalbuminuria) in type 1 diabetes ( 27647854) Tinnitus ( 33742053) Word spelling ( 30741946)
Interacting Genes		211 interacting genes: AANAT ABL1 ADAM22 ADRA2A ADRA2B ADRA2C AKAP13 AKT1 APP ARHGEF2 ATP5F1A ATXN1 BAD BCAR1 BCR BRAF BSPRY CBL CCDC125 CDC25A CDC25B CDC25C CDC5L CDK11B CDK16 CDK17 CDKN1B CENPJ CEP126 CEP131 CFL1 CGNL1 CLIC4 COP1 CRTC2 CSF2RB CSNK1A1 CSNK1D DFFA DISC1 EFNB3 EGFR EIF3A ENO1 EP300 EPB41L1 EPB41L2 EPB41L3 ERBB2 ERBB3 EXO1 FAM13B FHOD1 FOXO1 FOXO3 FOXO4 GABARAPL2 GABBR1 GCH1 GP1BA GP1BB GP5 GPSM3 GSK3B H3C1 HDAC4 HDAC6 HDAC9 HIVEP2 HMGN1 HSP90AA1 HSPA1A HSPA1B HSPB1 IGF1R IL9R ING1 INPP5A IRAG2 IRS1 IRS2 ITPRID2 KANK1 KCNK15 KCNK3 KCNK9 KIAA0232 KIAA0930 KIF1C KIF5B KLC2 KLC4 KLF11 KRT18 KSR1 LARP1 LATS2 LCP2 LIMK1 LNX1 LYST MADD MAP2K5 MAP3K2 MAP3K20 MAP3K3 MAP3K4 MAP3K5 MAPK8 MAPKAPK2 MAPT MARK2 MARK3 MARK4 MDM4 MEF2C MINK1 MLF1 MPHOSPH9 MSL2 MST1R MTNR1A MYH9 NEDD4L NFATC2 NFATC4 NR4A1 PAK1 PAK4 PARD3 PARD6A PARD6B PDC PFKFB2 PIAS1 PIK3R1 PPP1CC PPP1R14A PPP1R3D PRDX2 PRKACA PRKAR1A PRKCA PRKCD PRKCI PRKCZ PRKD1 PRLR PRMT5 PSMA5 PTPN13 PTPRO RAF1 RALGPS2 RAP1GAP2 RASAL3 REM1 RGS3 RIN1 RPRD1A RRAD SAMSN1 SH3GL1 SIK1 SIK3 SIMC1 SLC8A2 SNAPIN SNX24 SORBS2 SQSTM1 SSX2IP STK25 STK38 SYN2 SYNPO SYNPO2 TAB2 TBC1D7 TBXA2R TERT TH TJP2 TLK2 TNFAIP3 TNS1 TP53 TPD52L1 TPH1 TRA2B TRIM21 TSC1 TSC2 TUBB UBC UBE3A UCHL5 UCP2 UCP3 USP8 VCP VIM WEE1 WNK1 WNK2 WWTR1 XRCC6 YAP1 YWHAE YWHAG ZNF839	24 interacting genes: APC ARHGAP29 BEX3 BRD7 CRHR1 CRIP2 CTNNB1 EFNB1 EFNB2 FADD FAS FASLG GHR MTNR1A NFKBIA NGFR PDLIM4 PKN2 PLEKHA1 PLEKHA2 PRKACA RAPGEF6 TRIP6 YWHAZ
Entrez ID		7534	5783
HPRD ID		03183	02602
Ensembl ID		ENSG00000164924	ENSG00000163629
Uniprot IDs		D0PNI1 P63104	Q12923
PDB IDs		1IB1 1QJA 1QJB 2C1J 2C1N 2O02 2WH0 3CU8 3NKX 3RDH 4BG6 4FJ3 4HKC 4IHL 4N7G 4N7Y 4N84 4WRQ 4ZDR 5D2D 5D3F 5EWZ 5EXA 5J31 5JM4 5M35 5M36 5M37 5NAS 5ULO 5WXN 5XY9 6EF5 6EJL 6EWW 6F08 6F09 6FN9 6FNA 6FNB 6FNC 6Q0K 6RLZ 6U2H 6XAG 6ZFD 6ZFG 7D8H 7D8P 7D9V	1D5G 1Q7X 1WCH 2M0Z 2M10 3LNX 3LNY 3PDZ 5GLJ
Enriched GO Terms of Interacting Partners?
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