XPC and XPA

Number of citations of the paper that reports this interaction (PubMedID 12486030)
27

Data Source:
BioGRID (pull down)

		XPC	XPA
Description		XPC complex subunit, DNA damage recognition and repair factor	XPA, DNA damage recognition and repair factor
Image
GO Annotations	Cellular Component	Nucleotide-excision Repair Complex Nucleotide-excision Repair Factor 2 Complex Nucleus Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytosol Plasma Membrane Intracellular Membrane-bounded Organelle XPC Complex Site Of DNA Damage	Nucleotide-excision Repair Factor 1 Complex Nucleus Nucleoplasm Cytoplasm Intercellular Bridge
	Molecular Function	Heteroduplex DNA Loop Binding Bubble DNA Binding Damaged DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity Protein Binding Protein-containing Complex Binding	Damaged DNA Binding Protein Binding Protein Domain Specific Binding Protein Homodimerization Activity Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Nucleotide-excision Repair, DNA Damage Recognition Pyrimidine Dimer Repair By Nucleotide-excision Repair DNA Repair Nucleotide-excision Repair Mismatch Repair Response To Xenobiotic Stimulus Response To UV-B Response To Auditory Stimulus Mitotic Intra-S DNA Damage Checkpoint Signaling Positive Regulation Of Transcription, DNA-templated UV-damage Excision Repair Regulation Of Mitotic Cell Cycle Phase Transition UV-damage Excision Repair, DNA Incision	Nucleotide-excision Repair, DNA Damage Recognition DNA Repair Base-excision Repair UV Protection Response To Auditory Stimulus Nucleotide-excision Repair, DNA Incision Protein Localization To Nucleus UV-damage Excision Repair Nucleotide-excision Repair Involved In Interstrand Cross-link Repair
Pathways		SUMOylation of DNA damage response and repair proteins DNA Damage Recognition in GG-NER Formation of Incision Complex in GG-NER	Formation of Incision Complex in GG-NER Dual Incision in GG-NER Formation of TC-NER Pre-Incision Complex Dual incision in TC-NER
Drugs
Diseases
GWAS		Hip circumference adjusted for BMI ( 34021172)	Hypothyroidism ( 27182965) Obesity-related traits ( 23251661) Serum thyroid-stimulating hormone levels ( 24852370) Thyroid cancer (Papillary, radiation-related) ( 20350937)
Interacting Genes		16 interacting genes: CETN2 DDB2 ERCC3 GTF2H1 LSM3 MDM2 MRPS25 PSMD4 RAD23A RAD23B RPA1 SMAD1 TDG USP7 XPA ZNF512B	52 interacting genes: AP2M1 ARID3A ATM ATR AURKA BMPR1A BUB1 DDB1 DDB2 DLC1 DVL3 ERCC1 ERCC4 ERCC6 FBXW7 GPN1 GTF2E2 GTF2H1 HERC2 MEOX2 MLH1 MLH3 MSH2 MSH3 MUTYH NDEL1 NRAS PCNA PDGFRL PICK1 PMS2 POLR1C PRDM16 PRKDC PSMB1 RASSF1 RB1 RHOU RPA1 RPA2 RPA4 SKIL SMAD2 SNPH SRC STK11 TBC1D7 TRIM27 VPS26C XAB2 XPC ZNF655
Entrez ID		7508	7507
HPRD ID		02046	02045
Ensembl ID		ENSG00000154767	ENSG00000136936
Uniprot IDs		Q01831 X5DRB1	P23025
PDB IDs		2A4J 2GGM 2OBH 2RVB	1D4U 1XPA 2JNW 6J44 6LAE 6RO4
Enriched GO Terms of Interacting Partners?
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