XDH and GRIP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		XDH	GRIP1
Description		xanthine dehydrogenase	glutamate receptor interacting protein 1
Image
GO Annotations	Cellular Component	Extracellular Space Peroxisome Cytosol Sarcoplasmic Reticulum	Endoplasmic Reticulum Membrane Cytosol Plasma Membrane Postsynaptic Density Dendrite Cytoplasmic Vesicle Neuron Projection Perikaryon Membrane Raft Postsynaptic Membrane Glutamatergic Synapse
	Molecular Function	Xanthine Dehydrogenase Activity Xanthine Oxidase Activity Iron Ion Binding Protein Binding Oxidoreductase Activity Protein Homodimerization Activity Molybdopterin Cofactor Binding Flavin Adenine Dinucleotide Binding 2 Iron, 2 Sulfur Cluster Binding Hypoxanthine Dehydrogenase Activity Hypoxanthine Oxidase Activity FAD Binding	Protein Binding Beta-catenin Binding Protein C-terminus Binding Signaling Receptor Complex Adaptor Activity Glucocorticoid Receptor Binding
	Biological Process	Allantoin Metabolic Process Negative Regulation Of Protein Phosphorylation Negative Regulation Of Endothelial Cell Proliferation Guanine Catabolic Process Inosine Catabolic Process Deoxyinosine Catabolic Process Adenosine Catabolic Process Deoxyadenosine Catabolic Process Deoxyguanosine Catabolic Process AMP Catabolic Process IMP Catabolic Process Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Lactation Hypoxanthine Catabolic Process Xanthine Catabolic Process Negative Regulation Of Gene Expression Iron-sulfur Cluster Assembly Negative Regulation Of Endothelial Cell Differentiation GMP Catabolic Process DGMP Catabolic Process DAMP Catabolic Process Negative Regulation Of Protein Kinase B Signaling Positive Regulation Of P38MAPK Cascade Negative Regulation Of Vascular Endothelial Growth Factor Signaling Pathway Positive Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Vasculogenesis	Dendrite Development Intracellular Signal Transduction Neurotransmitter Receptor Transport, Endosome To Postsynaptic Membrane Vesicle-mediated Transport In Synapse Positive Regulation Of Neuron Projection Arborization
Pathways		Purine catabolism Butyrophilin (BTN) family interactions	Trafficking of GluR2-containing AMPA receptors
Drugs		Allopurinol Levocarnitine Topiroxostat Flavin adenine dinucleotide Dioxo(sulfanyl)molybdenum Eniluracil Niraxostat Febuxostat Oxypurinol
Diseases
GWAS		Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Aspartate aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Male-pattern baldness ( 28196072) Multiple system atrophy ( 27629089) Obesity-related traits ( 23251661) Parahippocampal gyrus volume ( 31530798) Periventricular white matter hyperintensities ( 32517579) Zinc levels ( 26025379)	Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252) Post bronchodilator FEV1/FVC ratio ( 26634245)
Interacting Genes		2 interacting genes: BTN1A1 GRIP1	44 interacting genes: AGAP2 AR CARM1 CSPG4 DEPDC1B DZIP3 EEPD1 EFNA5 EFNB1 EFNB2 EP300 ESR1 FGF12 FLII FXR1 FXR2 GPR37 GRIA1 GRIA3 GRIA4 GRIK1 GRIK2 GRIPAP1 GRM2 GRM3 GRM7 H3C1 HUS1 IRF3 MFAP3 NCOA6 NEK6 NR3C1 NUMBL PICK1 PPARG PRKD2 PRMT1 RXRA THRA UBE2I VDR WDR6 XDH
Entrez ID		7498	23426
HPRD ID		06363	19086
Ensembl ID		ENSG00000158125	ENSG00000155974
Uniprot IDs		P47989	Q9Y3R0
PDB IDs		2CKJ 2E1Q	2JIL
Enriched GO Terms of Interacting Partners?
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