WT1 and TAOK1

Number of citations of the paper that reports this interaction (PubMedID 21900206)
136

Data Source:
BioGRID (two hybrid)

		WT1	TAOK1
Description		WT1 transcription factor	TAO kinase 1
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Nuclear Speck	Cytoplasm Cytosol Microtubule Cytoskeleton Perinuclear Region Of Cytoplasm Extracellular Exosome
	Molecular Function	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity RNA Binding Protein Binding Zinc Ion Binding Double-stranded Methylated DNA Binding Sequence-specific DNA Binding Hemi-methylated DNA-binding C2H2 Zinc Finger Domain Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Alpha-tubulin Binding Protein Serine/threonine Kinase Activator Activity Tau Protein Binding Beta-tubulin Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Kidney Development Regulation Of Animal Organ Formation Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Germ Cell Development Thorax And Anterior Abdomen Determination Heart Development Sex Determination Negative Regulation Of Cell Population Proliferation RNA Splicing Gonad Development Male Gonad Development Tissue Development Positive Regulation Of Gene Expression Negative Regulation Of Cell Growth Adrenal Gland Development Male Genitalia Development Epithelial Cell Differentiation Glomerulus Development Glomerular Basement Membrane Development Adrenal Cortex Formation Camera-type Eye Development Negative Regulation Of Apoptotic Process Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Mesenchymal To Epithelial Transition Positive Regulation Of Heart Growth Diaphragm Development Cardiac Muscle Cell Fate Commitment Visceral Serous Pericardium Development Cellular Response To CAMP Cellular Response To Gonadotropin Stimulus Metanephric Mesenchyme Development Glomerular Visceral Epithelial Cell Differentiation Posterior Mesonephric Tubule Development Metanephric Epithelium Development Metanephric S-shaped Body Morphogenesis Negative Regulation Of Metanephric Glomerular Mesangial Cell Proliferation Positive Regulation Of Pri-miRNA Transcription By RNA Polymerase II Positive Regulation Of DNA Methylation Positive Regulation Of Male Gonad Development Negative Regulation Of Female Gonad Development Positive Regulation Of Metanephric Ureteric Bud Development	MAPK Cascade Microtubule Cytoskeleton Organization DNA Repair Protein Phosphorylation Cellular Response To DNA Damage Stimulus Negative Regulation Of Microtubule Depolymerization Mitotic G2 DNA Damage Checkpoint Signaling Phosphorylation Positive Regulation Of Stress-activated MAPK Cascade Regulation Of Actin Cytoskeleton Organization Intracellular Signal Transduction Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Protein Autophosphorylation Neuron Projection Morphogenesis Regulation Of Cytoskeleton Organization Neuron Cellular Homeostasis Regulation Of Microtubule Cytoskeleton Organization Positive Regulation Of Protein Serine/threonine Kinase Activity Execution Phase Of Apoptosis Positive Regulation Of Protein Acetylation
Pathways		Transcriptional regulation of testis differentiation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs			Fostamatinib
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Birth weight ( 31043758) Coronary artery disease ( 33020668) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Endometrial cancer ( 30093612) Endometrial cancer (endometrioid histology) ( 30093612) Inguinal hernia ( 26686553) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Medication use (diuretics) ( 31015401) Offspring birth weight ( 31043758) Pelvic organ prolapse ( 32184442) PR interval ( 32439900) Pulse pressure ( 30224653) Resting-state electroencephalogram vigilance ( 29703947) Rubella-specific interleukin-6 secretion ( 29253144) Tuberculosis ( 24057671 22306650) Uterine fibroids ( 31249589 30194396 31649266) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Body shape index ( 34021172) Mean platelet volume ( 22139419 24026423 19110211 19820697 32888494 22423221 27863252) Platelet count ( 22139419 29066854 32888494) Red cell distribution width ( 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		73 interacting genes: AREG B3GNT3 BHLHE40 BST2 CALML5 CAPRIN1 CASZ1 CCDC136 CCDC33 CCL5 CEP70 CIAO1 CREBBP CYSRT1 DIRAS3 DVL2 DVL3 EGR1 ETV7 FAM9B FHL2 FJX1 FMR1NB GLIS2 GOLGA2 HIPK3 HMBOX1 IDI1 IPO8 KLK7 KPNA4 KPNA5 KRT40 KRTAP10-1 KRTAP10-3 KRTAP10-4 KRTAP10-5 KRTAP10-6 KRTAP10-7 KRTAP10-8 KRTAP10-9 LDOC1 MAGEA8 MDM2 MYC NAT2 NPM3 OGT OSBPL3 PAWR PAX2 PAX6 PEX3 PICK1 PRKACA RNASEH2B SERF2 SOX4 STK11 TAOK1 THAP1 THRSP TP53 TP63 TP73 TRIM55 TRIM63 U2AF2 UBE2I WTAP WTIP ZNF205 ZRANB1	8 interacting genes: C8orf33 CSNK1E DYNC1I1 GEMIN7 MAP2K3 MARK1 NUFIP2 WT1
Entrez ID		7490	57551
HPRD ID		06163	15467
Ensembl ID		ENSG00000184937	ENSG00000160551
Uniprot IDs		P19544 Q6PI38	A0A024QZ70 Q7L7X3
PDB IDs		1LU6 1XF7 2G7T 2G7V 2G7W 2G7X 2JP9 2JPA 2PRT 3HPJ 3MYJ 4R2E 4R2P 4R2Q 4R2R 4R2S 4WUU 5KL2 5KL3 5KL4 5KL5 5KL6 5KL7 6B0O 6B0P 6B0Q 6B0R 6BLW 6RSY 6WLH
Enriched GO Terms of Interacting Partners?
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