WNT10B and MCPH1

Number of citations of the paper that reports this interaction (PubMedID 29150431)
8

Data Source:
BioGRID (two hybrid)

		WNT10B	MCPH1
Description		Wnt family member 10B	microcephalin 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Nucleoplasm Cytoplasm Microtubule Organizing Center
	Molecular Function	Frizzled Binding Cytokine Activity Protein Binding Receptor Ligand Activity	Protein Binding Identical Protein Binding
	Biological Process	G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Chondrocyte Differentiation Lipid Metabolic Process Smoothened Signaling Pathway Positive Regulation Of Cell Population Proliferation Positive Regulation Of G2/M Transition Of Mitotic Cell Cycle Myoblast Differentiation Involved In Skeletal Muscle Regeneration Neuron Differentiation Positive Regulation Of Bone Mineralization Positive Regulation Of Epithelial Cell Differentiation Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Apoptotic Process Cell Fate Commitment Negative Regulation Of Fat Cell Differentiation Positive Regulation Of Osteoblast Differentiation Positive Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Regulation Of Skeletal Muscle Tissue Development Skeletal Muscle Fiber Development Negative Regulation Of Epithelial Cell Proliferation Protein Stabilization Sensory Perception Of Taste Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of Timing Of Anagen Canonical Wnt Signaling Pathway Bone Trabecula Formation Fungiform Papilla Development Cellular Response To Retinoic Acid Cellular Response To CAMP Cellular Response To Parathyroid Hormone Stimulus Hematopoietic Stem Cell Proliferation Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis	Negative Regulation Of Transcription By RNA Polymerase II Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Cerebral Cortex Development Regulation Of Kinase Activity Regulation Of Centrosome Cycle Regulation Of Inflammatory Response Bone Development Regulation Of Chromosome Condensation Protein Localization To Centrosome Neuronal Stem Cell Population Maintenance
Pathways		WNT ligand biogenesis and trafficking WNT ligand biogenesis and trafficking Class B/2 (Secretin family receptors) Transcriptional regulation of white adipocyte differentiation	Condensation of Prophase Chromosomes
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756)	Alcoholic chronic pancreatitis ( 28754779) Birth weight ( 31043758) Carotid intima media thickness ( 30510157) Carotid intima media thickness (mean) ( 31801372) Cytomegalovirus antibody response ( 21993531) Diastolic blood pressure ( 30224653) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Epirubicin-induced leukopenia ( 21799462) Estimated glomerular filtration rate ( 31152163) Gut microbiota relative abundance (Faecalibacterium) ( 33208821) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010) Metabolite levels ( 23823483) Post bronchodilator FEV1/FVC ratio ( 26634245) Venlafaxine response in generalised anxiety disorder (remitters vs non-remitters after 24 weeks) ( 28437668)
Interacting Genes		1 interacting genes: MCPH1	68 interacting genes: ABCC2 ACTG1 AKIP1 AKR7A2 ATM ATR B3GALT6 CCDC77 CCT5 CHEK1 COL1A1 COL27A1 COPB2 COPS3 CTSL DNAJA3 DNAJC19 EIF3F EIF4A2 EMG1 ENO1 FBLN1 FLNA GABARAPL2 HNRNPA2B1 HSPD1 KAT5 KDM1A LAMTOR5 LGALS3 MCM2 MCM5 MITD1 MRPL46 MT2A NCCRP1 NMI NR2F1 OBSL1 PHF11 PMVK POLD1 POLR2G PPA1 PPRC1 RACK1 RBM39 RSL24D1 RUVBL2 S100A16 SMARCB1 SMARCC2 SMOX SUPT6H TADA2A TAF1D THAP11 TPT1 TRAP1 TSEN54 UXT VIM WDR53 WDR61 WDR73 WDR75 WNT10B ZMIZ2
Entrez ID		7480	79648
HPRD ID		03548	06174
Ensembl ID		ENSG00000169884	ENSG00000147316
Uniprot IDs		O00744	Q8NEM0
PDB IDs			2WT8 3KTF 3PA6 3SHT 3SHV 3SZM 3T1N 3U3Z 7C5D
Enriched GO Terms of Interacting Partners?
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