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VCP and NOD2
Number of citations of the paper that reports this interaction (PubMedID
27812135
)
4
Data Source:
BioGRID
(two hybrid)
VCP
NOD2
Description
valosin containing protein
nucleotide binding oligomerization domain containing 2
Image
No pdb structure
GO Annotations
Cellular Component
Proteasome Complex
Extracellular Region
Nucleus
Nucleoplasm
Cytoplasm
Endoplasmic Reticulum
Endoplasmic Reticulum Membrane
Lipid Droplet
Cytosol
Cytoplasmic Stress Granule
Protein-containing Complex
VCP-NPL4-UFD1 AAA ATPase Complex
Secretory Granule Lumen
Azurophil Granule Lumen
Site Of Double-strand Break
Derlin-1 Retrotranslocation Complex
Intracellular Membrane-bounded Organelle
Perinuclear Region Of Cytoplasm
Extracellular Exosome
Glutamatergic Synapse
Ficolin-1-rich Granule Lumen
ATPase Complex
VCP-NSFL1C Complex
Cytoplasm
Mitochondrion
Golgi Apparatus
Cytosol
Cytoskeleton
Plasma Membrane
Cell Surface
Basolateral Plasma Membrane
Vesicle
Protein-containing Complex
Phagocytic Vesicle
Anchored Component Of Plasma Membrane
Molecular Function
RNA Binding
Protein Binding
ATP Binding
Lipid Binding
ATP Hydrolysis Activity
Protein Phosphatase Binding
Protein Domain Specific Binding
Polyubiquitin Modification-dependent Protein Binding
Ubiquitin Protein Ligase Binding
Deubiquitinase Activator Activity
K48-linked Polyubiquitin Modification-dependent Protein Binding
MHC Class I Protein Binding
Identical Protein Binding
ADP Binding
Ubiquitin-like Protein Ligase Binding
BAT3 Complex Binding
Ubiquitin-specific Protease Binding
Actin Binding
Protein Binding
ATP Binding
Enzyme Binding
Protein Kinase Binding
Hsp70 Protein Binding
Muramyl Dipeptide Binding
Pattern Recognition Receptor Activity
Peptidoglycan Binding
Protein-containing Complex Binding
CARD Domain Binding
Hsp90 Protein Binding
Biological Process
DNA Repair
Double-strand Break Repair
NADH Metabolic Process
Endoplasmic Reticulum To Golgi Vesicle-mediated Transport
Autophagy
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Cellular Response To DNA Damage Stimulus
Proteasomal Protein Catabolic Process
Positive Regulation Of Mitochondrial Membrane Potential
Macroautophagy
Protein Ubiquitination
Viral Genome Replication
Translesion Synthesis
Ubiquitin-dependent ERAD Pathway
Endoplasmic Reticulum Unfolded Protein Response
Retrograde Protein Transport, ER To Cytosol
Positive Regulation Of Protein-containing Complex Assembly
Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process
Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway
Cellular Response To Heat
Stress Granule Disassembly
Interstrand Cross-link Repair
ERAD Pathway
Regulation Of Apoptotic Process
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Establishment Of Protein Localization
Positive Regulation Of Protein Catabolic Process
Negative Regulation Of Smoothened Signaling Pathway
ATP Metabolic Process
Regulation Of Synapse Organization
Mitotic Spindle Disassembly
Endoplasmic Reticulum Stress-induced Pre-emptive Quality Control
Aggresome Assembly
ER-associated Misfolded Protein Catabolic Process
Flavin Adenine Dinucleotide Catabolic Process
Positive Regulation Of Canonical Wnt Signaling Pathway
Autophagosome Maturation
Protein-DNA Covalent Cross-linking Repair
Positive Regulation Of Protein K63-linked Deubiquitination
Positive Regulation Of Lys63-specific Deubiquitinase Activity
Regulation Of Aerobic Respiration
Cellular Response To Arsenite Ion
Positive Regulation Of Oxidative Phosphorylation
Regulation Of Protein Localization To Chromatin
Positive Regulation Of Ubiquitin-specific Protease Activity
Positive Regulation Of ATP Biosynthetic Process
Pattern Recognition Receptor Signaling Pathway
Innate Immune Response In Mucosa
Activation Of Immune Response
Positive Regulation Of Dendritic Cell Antigen Processing And Presentation
Negative Regulation Of T Cell Mediated Immunity
Positive Regulation Of Cytokine Production Involved In Immune Response
Positive Regulation Of Dendritic Cell Cytokine Production
Positive Regulation Of Type 2 Immune Response
Negative Regulation Of Inflammatory Response To Antigenic Stimulus
Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin
Defense Response
Positive Regulation Of Biosynthetic Process Of Antibacterial Peptides Active Against Gram-positive Bacteria
Response To Nutrient
Detection Of Biotic Stimulus
Detection Of Bacterium
Maintenance Of Gastrointestinal Epithelium
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Muramyl Dipeptide
Detection Of Muramyl Dipeptide
Negative Regulation Of Interferon-gamma Production
Negative Regulation Of Interleukin-12 Production
Negative Regulation Of Interleukin-18 Production
Negative Regulation Of Interleukin-2 Production
Negative Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-10 Production
Positive Regulation Of Interleukin-12 Production
Positive Regulation Of Interleukin-17 Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Interleukin-8 Production
Positive Regulation Of Tumor Necrosis Factor Production
Positive Regulation Of Stress-activated MAPK Cascade
Negative Regulation Of Toll-like Receptor 2 Signaling Pathway
Intracellular Signal Transduction
Defense Response To Bacterium
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Exogenous DsRNA
Positive Regulation Of MAP Kinase Activity
Positive Regulation Of Phosphatidylinositol 3-kinase Activity
Innate Immune Response
Positive Regulation Of Innate Immune Response
Positive Regulation Of Notch Signaling Pathway
Positive Regulation Of Transcription By RNA Polymerase II
Positive Regulation Of JNK Cascade
Positive Regulation Of Gamma-delta T Cell Activation
Positive Regulation Of Epithelial Cell Proliferation
Regulation Of Inflammatory Response
Positive Regulation Of Peptidyl-tyrosine Phosphorylation
Positive Regulation Of Phagocytosis
Defense Response To Gram-positive Bacterium
Positive Regulation Of B Cell Activation
Positive Regulation Of NF-kappaB Transcription Factor Activity
Positive Regulation Of Oxidoreductase Activity
Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Positive Regulation Of Prostaglandin-endoperoxide Synthase Activity
Positive Regulation Of ERK1 And ERK2 Cascade
Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway
Cellular Response To Lipopolysaccharide
Cellular Response To Peptidoglycan
Cellular Response To Muramyl Dipeptide
Cellular Response To Organic Cyclic Compound
Positive Regulation Of Monocyte Chemotactic Protein-1 Production
Regulation Of Neutrophil Chemotaxis
Positive Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of Protein K63-linked Ubiquitination
Positive Regulation Of Xenophagy
Negative Regulation Of Macrophage Apoptotic Process
Positive Regulation Of Prostaglandin-E Synthase Activity
Pathways
Translesion Synthesis by POLH
HSF1 activation
ABC-family proteins mediated transport
N-glycan trimming in the ER and Calnexin/Calreticulin cycle
Hedgehog ligand biogenesis
Hh mutants are degraded by ERAD
Defective CFTR causes cystic fibrosis
Josephin domain DUBs
Ovarian tumor domain proteases
Neutrophil degranulation
E3 ubiquitin ligases ubiquitinate target proteins
Protein methylation
RHOH GTPase cycle
Aggrephagy
Attachment and Entry
Attachment and Entry
NOD1/2 Signaling Pathway
NOD1/2 Signaling Pathway
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
activated TAK1 mediates p38 MAPK activation
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
Ovarian tumor domain proteases
Interleukin-1 signaling
Drugs
Phosphoaminophosphonic Acid-Adenylate Ester
Phenethyl Isothiocyanate
Mifamurtide
Diseases
GWAS
Response to quetiapine in schizophrenia (
29503163
)
Asthma (
31361310
30929738
32296059
)
Asthma (childhood onset) (
31036433
30929738
)
Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) (
26974007
)
Crohn's disease (
18587394
28067908
20570966
22936669
22412388
17554300
21102463
23128233
17804789
)
Inflammatory bowel disease (
18758464
28067908
)
Leprosy (
20018961
27976721
25642632
)
Medication use (thyroid preparations) (
31015401
)
Parkinson's disease or first degree relation to individual with Parkinson's disease (
31701892
)
Pediatric autoimmune diseases (
26301688
)
Interacting Genes
96 interacting genes:
ABHD17C
AMFR
ANKRD13A
AR
ASPSCR1
ATG5
ATXN1
ATXN3
ATXN7
BAG5
BRCA1
BRSK2
BUD23
CACNA1C
CEP19
CLUAP1
CRMP1
CSTF1
DERL1
DGCR6
DTNB
ELAVL1
EPSTI1
ESR1
FAF2
FAM104A
GZMK
HDAC6
HERPUD1
HTT
INSIG1
INSIG2
JAK2
LINC01554
LNX1
LZIC
MAPK8IP2
METTL17
NDRG1
NF1
NFKBIA
NGLY1
NOD2
NPLOC4
NSFL1C
NTAQ1
NUB1
OPTN
PIK3R3
PLAA
PPP1R11
PPP1R3A
PRKCD
PSMA1
PSMA7
PSMC1
PTPN3
RNF115
RNF19A
RNF8
RPL9
RPS6KA1
SELENOS
SH2D2A
SIGMAR1
SLC43A3
STUB1
STX5
SUMO4
SVIP
TOM1L1
TOMM34
TRIM54
UBASH3A
UBC
UBE4A
UBE4B
UBOX5
UBXN10
UBXN11
UBXN2A
UBXN2B
UBXN4
UBXN6
UBXN7
UFD1
USP7
VAMP2
VCPIP1
VCPKMT
WAC
WRN
XAF1
YOD1
YWHAZ
ZBTB25
40 interacting genes:
ALPI
ANKHD1
ANXA2
ATG16L1
C10orf67
CCL13
CHMP4B
CHMP5
CNOT1
DCTN1
DOCK7
ENTR1
ERBIN
GOLGA6L5P
GOLGB1
HAP1
IKBIP
IRGM
LDOC1
LMNA
LURAP1L
MAP3K7
NLRC4
PDLIM5
PPP1R12C
PPP2R3B
PRR16
RIPK2
RPL13A
SCYL1
SETD6
TACC3
TNIP1
TPM1
TPM3
TPM4
TRIM41
VCP
WBP11
XIAP
Entrez ID
7415
64127
HPRD ID
03013
05810
Ensembl ID
ENSG00000165280
ENSG00000167207
Uniprot IDs
P55072
V9HW80
A0A286YF65
Q9HC29
PDB IDs
3EBB
3HU1
3HU2
3HU3
3QC8
3QQ7
3QQ8
3QWZ
3TIW
4KDI
4KDL
4KLN
4KO8
4KOD
4P0A
5B6C
5C18
5C19
5C1A
5C1B
5DYG
5DYI
5EPP
5FTJ
5FTK
5FTL
5FTM
5FTN
5GLF
5IFS
5IFW
5KIW
5KIY
5X4L
6G2V
6G2W
6G2X
6G2Y
6G2Z
6G30
6HD0
6MCK
7JY5
Enriched GO Terms of Interacting Partners
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