KDM6A and ZNF157

		KDM6A	ZNF157
Description		lysine demethylase 6A	zinc finger protein 157
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex MLL3/4 Complex	Nucleus
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Protein Binding Chromatin DNA Binding Histone Demethylase Activity Metal Ion Binding Dioxygenase Activity Histone H3-tri/di-methyl-lysine-27 Demethylase Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding
	Biological Process	Chromatin Remodeling Heart Development Regulation Of Gene Expression Histone H3-K4 Methylation Histone H3-K27 Demethylation	Regulation Of Transcription By RNA Polymerase II
Pathways		HDMs demethylate histones Activation of anterior HOX genes in hindbrain development during early embryogenesis	Generic Transcription Pathway
Drugs
Diseases
GWAS			Optic nerve measurement (disc area) ( 20395239)
Interacting Genes		19 interacting genes: AKAP4 BMP15 CREBBP ELK1 GSC2 H3-4 H3C1 H3C14 HSD17B10 MAGED2 MEOX2 MTDH NKX2-5 RBM3 SMAD9 SRF TBX5 TLE1 ZNF157	1 interacting genes: KDM6A
Entrez ID		7403	7712
HPRD ID		02131	02064
Ensembl ID		ENSG00000147050	ENSG00000147117
Uniprot IDs		A0A087X0R0 A0A6Q8PFK0 B4E0L8 B7ZKN1 B7ZKN5 B7ZKN6 E1U0S6 F5H5V6 F5H6S1 F8W8R6 O15550 Q59HG3 Q86TD1	P51786
PDB IDs		3AVR 3AVS 6FUK 6FUL
Enriched GO Terms of Interacting Partners?
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