UTRN and MARK2

Number of citations of the paper that reports this interaction (PubMedID 19945424)
23

Data Source:
BioGRID (pull down, enzymatic study)

		UTRN	MARK2
Description		utrophin	microtubule affinity regulating kinase 2
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Cytoskeleton Plasma Membrane Dystrophin-associated Glycoprotein Complex Membrane Cell Junction Filopodium Cortical Actin Cytoskeleton Filopodium Membrane Neuromuscular Junction Protein-containing Complex Sarcolemma Cell Projection Postsynaptic Membrane Extracellular Exosome Contractile Ring	Nucleoplasm Cytoplasm Mitochondrion Actin Filament Plasma Membrane Membrane Lateral Plasma Membrane Dendrite Microtubule Bundle
	Molecular Function	Actin Binding Integrin Binding Protein Binding Zinc Ion Binding Vinculin Binding Protein Kinase Binding Actin Filament Binding	Magnesium Ion Binding RNA Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Lipid Binding Protein Kinase Activator Activity Cadherin Binding Tau Protein Binding Tau-protein Kinase Activity Protein Serine Kinase Activity
	Biological Process	Positive Regulation Of Cell-matrix Adhesion Muscle Contraction Muscle Organ Development Actin Cytoskeleton Organization Regulation Of Sodium Ion Transmembrane Transporter Activity	Microtubule Cytoskeleton Organization Autophagy Of Mitochondrion Neuron Migration Protein Phosphorylation Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Establishment Of Cell Polarity Activation Of Protein Kinase Activity Intracellular Signal Transduction Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Protein Autophosphorylation Regulation Of Axonogenesis Regulation Of Cytoskeleton Organization Mitochondrion Localization Axon Development Regulation Of Microtubule Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Regulation Of Microtubule Binding
Pathways		EGR2 and SOX10-mediated initiation of Schwann cell myelination
Drugs		Zinc Zinc acetate Zinc chloride Zinc sulfate, unspecified form	Fostamatinib
Diseases
GWAS		Age at first sexual intercourse ( 34211149) Loneliness (multivariate analysis) ( 27629369) Multisite chronic pain ( 33830993 31194737) Peripheral arterial disease (traffic-related air pollution interaction) ( 27082954) Refractive error ( 32231278) Remission after SSRI treatment in MDD or openness ( 29559929) Response to fenofibrate (triglyceride levels) ( 27002377) Response to mepolizumab in severe asthma ( 29229094) Response to SSRI in MDD or openness ( 29559929) Restless legs syndrome in migraine without aura ( 32918390)	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure) ( 21130132)
Interacting Genes		22 interacting genes: ACTA1 ACTN2 C1QTNF9 CALM1 DAG1 DISC1 DMD DRP2 DTNA DTNB ITGB1BP1 MARCHF5 MARK2 NUP98 PGM5 PRKACA PTEN PTPN12 SASH1 SNTA1 SNTB1 SNTB2	42 interacting genes: BAIAP2 CAMK1 CASK DVL3 FBXO7 FLRT1 GAB1 GSK3B HDAC7 INCENP ISOC1 KIF13B KIFAP3 MAP3K3 MAPT MTCL1 NEDD4 NEDD4L NUAK1 NXF1 OSBP PARD3B PARD6A PINK1 PKD1 PLAAT3 PPP2R5B PRKCE PTPRD RAB11FIP2 RNF41 RPA2 RPS6KB1 SCGB1A1 SMURF1 STK11 STK3 STK4 UTRN YWHAB YWHAQ YWHAZ
Entrez ID		7402	2011
HPRD ID		00547	02753
Ensembl ID		ENSG00000152818	ENSG00000072518
Uniprot IDs		P46939 Q6LBS5	A0A140VJP1 A8K2S4 E7ETY4 Q7KZI7
PDB IDs		1BHD 1QAG 6M5G	3IEC 5EAK 5KZ7 5KZ8
Enriched GO Terms of Interacting Partners?
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