UBTF and IRS2

Number of citations of the paper that reports this interaction (PubMedID 12554758)
29

Data Source:
HPRD (in vivo)

		UBTF	IRS2
Description		upstream binding transcription factor	insulin receptor substrate 2
Image
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nucleoplasm Nucleolus	Cytosol Plasma Membrane Protein-containing Complex
	Molecular Function	RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Cis-regulatory Region Sequence-specific DNA Binding RNA Polymerase I General Transcription Initiation Factor Activity Chromatin Binding RNA Binding Protein Binding Scaffold Protein Binding	Insulin Receptor Binding Protein Binding Protein Kinase Binding Protein Phosphatase Binding Protein Domain Specific Binding Phosphatidylinositol 3-kinase Binding 14-3-3 Protein Binding
	Biological Process	RNA Polymerase I Preinitiation Complex Assembly Transcription By RNA Polymerase I Transcription Initiation From RNA Polymerase I Promoter Positive Regulation Of Transcription By RNA Polymerase I Regulation Of Glucose Mediated Signaling Pathway	Positive Regulation Of Mesenchymal Cell Proliferation Negative Regulation Of B Cell Apoptotic Process Glucose Metabolic Process Signal Transduction Brain Development Positive Regulation Of Cell Population Proliferation Insulin Receptor Signaling Pathway Response To Glucose Negative Regulation Of Long-chain Fatty Acid Import Across Plasma Membrane Positive Regulation Of Glucose Metabolic Process Regulation Of Lipid Metabolic Process Positive Regulation Of Cell Migration Mammary Gland Development Positive Regulation Of B Cell Proliferation Positive Regulation Of Fatty Acid Beta-oxidation Positive Regulation Of Insulin Secretion Cellular Response To Insulin Stimulus Negative Regulation Of Kinase Activity Positive Regulation Of Glycogen Biosynthetic Process Positive Regulation Of Glucose Import Lipid Homeostasis Cellular Response To Glucose Stimulus
Pathways		NoRC negatively regulates rRNA expression RNA Polymerase I Promoter Opening RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination	PI3K Cascade IRS-mediated signalling SOS-mediated signalling SOS-mediated signalling PIP3 activates AKT signaling Interleukin-7 signaling PI3K/AKT activation PI3K/AKT activation Constitutive Signaling by Aberrant PI3K in Cancer IRS-related events triggered by IGF1R Signaling by Leptin RAF/MAP kinase cascade PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling IRS activation Signal attenuation RET signaling Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS Growth hormone receptor signaling
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Diverticular disease ( 30177863) hemolysis of donated blood (osmotic) ( 34014839) Mean corpuscular hemoglobin concentration ( 29403010) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892)	Alanine aminotransferase levels ( 34315874) Antipsychotic drug-induced weight gain in schizophrenia ( 31447353) Aspartate aminotransferase levels ( 34315874) Heel bone mineral density ( 30598549 28869591) Hematocrit ( 32888494) Hemoglobin ( 32888494) Hemoglobin levels ( 32327693) High light scatter reticulocyte count ( 32888494) Insulin-related traits (multivariate analysis) ( 32002517) Mean corpuscular hemoglobin ( 29403010 32888494 27863252) Mean corpuscular volume ( 29403010 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Nose size ( 27182965) Paclitaxel disposition in epithelial ovarian cancer ( 29367611) Platelet count ( 29403010) Prostate cancer ( 29117387) Red cell distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494 27863252) Type 2 diabetes ( 30297969) Vertical cup-disc ratio (multi-trait analysis) ( 31959993) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)
Interacting Genes		34 interacting genes: AURKA CCNA2 CCND1 CCNE1 CDK2 CDK4 CENPC CHGB CREBBP CSNK2A1 EP300 GSK3A IRS1 IRS2 LEF1 MAD1L1 MAPK1 MAPK3 MDM2 POLR1E POLR1G RB1 RBL2 RUNX2 SERPINH1 SMURF1 TAF1 TAF1A TAF1B TAF1C TAF1D TBP TCOF1 ZMYM2	50 interacting genes: ATP2A1 ATP2A2 BCL2L1 CDKL1 CRK CUL4A EDEM1 EPOR FES GRB2 IGF1R IL4R INSR JAK1 JAK2 JAK3 LAMP1 MPL MPO MTDH NEDD4 NRAS NTRK1 PIK3CA PIK3CD PIK3R1 PIK3R2 PIK3R3 PLCG1 PROZ PTPN11 PTPN6 PTPRF PTPRR RAP2A RPTOR SHC1 SLC35B1 SOCS1 SOCS3 SOCS6 SOCS7 SRPK2 TYK2 UBTF YWHAB YWHAE YWHAG YWHAQ YWHAZ
Entrez ID		7343	8660
HPRD ID		02814	02878
Ensembl ID		ENSG00000108312	ENSG00000185950
Uniprot IDs		P17480	Q9P084 Q9Y4H2
PDB IDs		1K99 1L8Y 1L8Z 2HDZ	3FQW 3FQX
Enriched GO Terms of Interacting Partners?
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