TYRO3 and KLK4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
484

Data Source:
BioGRID (two hybrid)

		TYRO3	KLK4
Description		TYRO3 protein tyrosine kinase	kallikrein related peptidase 4
Image
GO Annotations	Cellular Component	Nucleus Nuclear Envelope Endoplasmic Reticulum Membrane Integral Component Of Plasma Membrane Cell Surface Receptor Complex	Extracellular Region Secretory Granule
	Molecular Function	Virus Receptor Activity Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phosphatidylinositol 3-kinase Binding	Serine-type Endopeptidase Activity Protein Binding Serine-type Peptidase Activity Metal Ion Binding
	Biological Process	Natural Killer Cell Differentiation Phagocytosis Cell Adhesion Signal Transduction Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Neuropeptide Signaling Pathway Multicellular Organism Development Spermatogenesis Nervous System Development Phosphatidylinositol 3-kinase Signaling Cell Migration Peptidyl-tyrosine Phosphorylation Forebrain Cell Migration Platelet Activation Secretion By Cell Positive Regulation Of Kinase Activity Negative Regulation Of Toll-like Receptor Signaling Pathway Substrate Adhesion-dependent Cell Spreading Ovulation Cycle Apoptotic Cell Clearance Protein Kinase B Signaling Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Innate Immune Response Viral Entry Into Host Cell Protein Autophosphorylation Negative Regulation Of Inflammatory Response Negative Regulation Of Lymphocyte Activation Vagina Development Neuron Cellular Homeostasis Platelet Aggregation Positive Regulation Of Viral Life Cycle	Proteolysis Extracellular Matrix Disassembly Biomineral Tissue Development Amelogenesis
Pathways
Drugs		Fostamatinib
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) HDL cholesterol levels ( 32203549) Metabolic syndrome ( 31589552) Microalbuminuria ( 31511532) Red blood cell count ( 32888494) Systemic lupus erythematosus ( 24871463) Urinary albumin-to-creatinine ratio ( 31630189 31511532)	Celiac disease ( 23936387) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Obesity-related traits ( 23251661)
Interacting Genes		28 interacting genes: A2M APOE AXL CTDSP1 CTDSP2 ERBB2 FYN GAS6 GRB2 IKBKG KLK4 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP4-2 KRTAP5-9 KRTAP9-2 LNX1 MDFI MGAT5B PIK3R1 PROS1 SRC TNIP1 VWC2L YES1	3 interacting genes: SERPINA3 SHBG TYRO3
Entrez ID		7301	9622
HPRD ID		02641	04793
Ensembl ID		ENSG00000092445	ENSG00000167749
Uniprot IDs		H0YNK6 Q06418	A0A0C4DFQ5 Q5BQA0 Q96PT1 Q9Y5K2
PDB IDs		1RHF	2BDG 2BDH 2BDI 4K1E 4K8Y 4KEL 4KGA 6KBR 6NVB 6O21
Enriched GO Terms of Interacting Partners?
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