TXN and APEX1

Number of citations of the paper that reports this interaction (PubMedID 9108029)
164

Data Source:
HPRD (in vivo, in vitro)

		TXN	APEX1
Description		thioredoxin	apurinic/apyrimidinic endodeoxyribonuclease 1
Image
GO Annotations	Cellular Component	Extracellular Region Nucleus Nucleoplasm Cytoplasm Cytosol Extracellular Exosome	Chromosome, Telomeric Region Nucleus Nucleoplasm Transcription Regulator Complex Nucleolus Cytoplasm Mitochondrion Endoplasmic Reticulum Centrosome Ribosome Nuclear Speck Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Binding Thioredoxin-disulfide Reductase Activity Protein Binding Protein-disulfide Reductase Activity Protein Homodimerization Activity Protein-disulfide Reductase (NAD(P)) Activity	DNA Binding Damaged DNA Binding Double-stranded Telomeric DNA Binding Transcription Coactivator Activity Transcription Corepressor Activity RNA Binding DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Endonuclease Activity Endodeoxyribonuclease Activity RNA-DNA Hybrid Ribonuclease Activity Phosphodiesterase I Activity Uracil DNA N-glycosylase Activity Protein Binding Phosphoric Diester Hydrolase Activity 3'-5'-exodeoxyribonuclease Activity Double-stranded DNA Exodeoxyribonuclease Activity Double-stranded DNA 3'-5' Exodeoxyribonuclease Activity 3'-5' Exonuclease Activity Oxidoreductase Activity Site-specific Endodeoxyribonuclease Activity, Specific For Altered Base Chromatin DNA Binding Protein-containing Complex Binding Metal Ion Binding NF-kappaB Binding Class II DNA-(apurinic Or Apyrimidinic Site) Endonuclease Activity Phosphodiesterase Activity, Acting On 3'-phosphoglycolate-terminated DNA Strands DNA-(abasic Site) Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Glycerol Ether Metabolic Process Response To Radiation Activation Of Protein Kinase B Activity Positive Regulation Of Peptidyl-serine Phosphorylation Positive Regulation Of DNA Binding Cell Redox Homeostasis Negative Regulation Of Protein Export From Nucleus Positive Regulation Of Protein Kinase B Signaling Response To Nitric Oxide Cellular Oxidant Detoxification Negative Regulation Of Hydrogen Peroxide-induced Cell Death Positive Regulation Of Peptidyl-cysteine S-nitrosylation	Telomere Maintenance DNA Catabolic Process, Endonucleolytic DNA Repair Base-excision Repair Base-excision Repair, Gap-filling DNA Recombination Aging Response To Xenobiotic Stimulus Negative Regulation Of Smooth Muscle Cell Migration Regulation Of Apoptotic Process Regulation Of MRNA Stability Cell Redox Homeostasis Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Cellular Response To Hydrogen Peroxide Cellular Response To CAMP Cellular Response To Peptide Hormone Stimulus DNA Demethylation RNA Phosphodiester Bond Hydrolysis, Endonucleolytic Telomere Maintenance Via Base-excision Repair Positive Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Oxidative Stress Induced Senescence Detoxification of Reactive Oxygen Species Interconversion of nucleotide di- and triphosphates TP53 Regulates Metabolic Genes Protein repair The NLRP3 inflammasome The NLRP3 inflammasome Regulation of FOXO transcriptional activity by acetylation Purinergic signaling in leishmaniasis infection Purinergic signaling in leishmaniasis infection	Displacement of DNA glycosylase by APEX1 POLB-Dependent Long Patch Base Excision Repair Resolution of AP sites via the multiple-nucleotide patch replacement pathway PCNA-Dependent Long Patch Base Excision Repair Abasic sugar-phosphate removal via the single-nucleotide replacement pathway Resolution of Abasic Sites (AP sites)
Drugs		Phenethyl Isothiocyanate	Lucanthone
Diseases
GWAS		Itch intensity from mosquito bite adjusted by bite size ( 28199695) Mean corpuscular hemoglobin ( 32888494) Mean reticulocyte volume ( 32888494)	Menopause (age at onset) ( 26414677)
Interacting Genes		38 interacting genes: ACTN1 ACTN4 ANKRD11 APEX1 CDKN1A COL1A1 COPS5 DDIT4L DNAJA1 DYNLT1 EGFR ERBB2 ERBB3 ERBB4 FST GFER GPRASP2 MAP3K5 MLH1 MRFAP1 MYD88 NCF4 NFE2 NFKB1 NIF3L1 NR3C1 NUP62 PTEN SERTAD3 SIAH1 SPG21 SRPK2 TEX13A TP53 TRAF2 TXNIP UCHL5 VIM	44 interacting genes: ANP32A ANP32C APP CDC42 CSNK2A1 DCTN1 EP300 FBXO7 FEN1 GZMA GZMK HDAC1 HIF1A HMGA1 HMGA2 HMGB2 HNRNPL HOXC13 HSPA1A LINC01554 MCL1 MDM2 MUTYH NFE2L2 NME1 NUDT3 NXF2 PCNA POLB POLR3D SET SRPK1 SRPK2 TCF21 TERF1 TERF2 TERF2IP TP53 TXN UBE2I UBR3 XRCC1 XRCC5 XRCC6
Entrez ID		7295	328
HPRD ID		01761	00136
Ensembl ID		ENSG00000136810	ENSG00000100823
Uniprot IDs		H9ZYJ2 P10599	P27695 Q5TZP7
PDB IDs		1AIU 1AUC 1CQG 1CQH 1ERT 1ERU 1ERV 1ERW 1M7T 1MDI 1MDJ 1MDK 1TRS 1TRU 1TRV 1TRW 1W1C 1W1E 2HSH 2HXK 2IFQ 2IIY 3E3E 3KD0 3M9J 3M9K 3QFA 3QFB 3TRX 4LL1 4LL4 4OO4 4OO5 4POK 4POL 4POM 4PUF 4TRX 5DQY	1BIX 1CQG 1CQH 1DE8 1DE9 1DEW 1E9N 1HD7 2ISI 2O3H 3U8U 4IEM 4LND 4QH9 4QHD 4QHE 5CFG 5DFF 5DFH 5DFI 5DFJ 5DG0 5WN0 5WN1 5WN2 5WN3 5WN4 5WN5 6BOQ 6BOR 6BOS 6BOT 6BOU 6BOV 6BOW 6MK3 6MKK 6MKM 6MKO 6P93 6P94 6W0Q 6W2P 6W3L 6W3N 6W3Q 6W3U 6W43 6W4I 6W4T
Enriched GO Terms of Interacting Partners?
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