TXK and STAP2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TXK	STAP2
Description		TXK tyrosine kinase	signal transducing adaptor family member 2
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Plasma Membrane	Cytosol Plasma Membrane
	Molecular Function	Protein Tyrosine Kinase Activity Transmembrane Receptor Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding	Protein Binding Signaling Adaptor Activity
	Biological Process	Positive Regulation Of Cytokine Production Adaptive Immune Response Protein Phosphorylation Activation Of Phospholipase C Activity Integrin-mediated Signaling Pathway Regulation Of Gene Expression Regulation Of Platelet Activation Positive Regulation Of Interferon-gamma Production Peptidyl-tyrosine Autophosphorylation Tissue Regeneration Positive Regulation Of Transcription By RNA Polymerase II Protein Autophosphorylation T Cell Receptor Signaling Pathway Positive Regulation Of Interferon-gamma-mediated Signaling Pathway
Pathways		FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization	PTK6 Activates STAT3 Cytoprotection by HMOX1
Drugs		Fostamatinib Zanubrutinib
Diseases
GWAS		Aspartate aminotransferase levels ( 33547301) Crohn's disease ( 23128233) Mean platelet volume ( 32888494) Multiple sclerosis ( 31604244) Platelet distribution width ( 32888494 27863252)	Tea consumption ( 31046077)
Interacting Genes		40 interacting genes: CBY2 CCDC33 CCR5 CLNK CRK CTLA4 DOK2 DUSP6 EFHC2 EGFR ERBB2 ERBB3 ERBB4 FYN GRB10 GRB2 HOMEZ IKZF1 IKZF4 JRK KIT LCP2 MET NCK2 NELFCD PIK3R1 PRDM14 RBAK SH2D2A SOCS3 SOCS6 SRC STAP2 TEC TNS4 UTP18 YTHDC1 ZNF587 ZNF792 ZNF835	18 interacting genes: BLK BMP4 CBL CHUK CSF1R EGFR IKBKB JAK2 KEAP1 MLH1 MYD88 PTK6 SRC STAT3 STAT5A STAT5B TXK YES1
Entrez ID		7294	55620
HPRD ID		02505	07430
Ensembl ID		ENSG00000074966	ENSG00000178078
Uniprot IDs		P42681	Q9UGK3
PDB IDs		2DM0	2EL8
Enriched GO Terms of Interacting Partners?
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