HIRA and PAX7

Number of citations of the paper that reports this interaction (PubMedID 9731536)
36

Data Source:
HPRD (two hybrid, in vitro)

		HIRA	PAX7
Description		histone cell cycle regulator	paired box 7
Image			No pdb structure
GO Annotations	Cellular Component	HIR Complex Chromatin Nucleus Nucleoplasm PML Body Protein-containing Complex Extracellular Exosome	Chromatin Nucleus
	Molecular Function	Transcription Corepressor Activity Protein Binding Nucleosome Binding Histone Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Sequence-specific Double-stranded DNA Binding
	Biological Process	DNA Replication-independent Nucleosome Assembly Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Anatomical Structure Morphogenesis Negative Regulation Of Transcription, DNA-templated	Regulation Of Transcription By RNA Polymerase II Muscle Organ Development Anatomical Structure Morphogenesis Negative Regulation Of Apoptotic Process Anatomical Structure Development
Pathways		Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Cognitive decline rate in late mild cognitive impairment ( 26252872)	Body mass index ( 23669352) Cleft lip with or without cleft palate ( 28054174) Cortical surface area (visual PC2) ( 32198502) Knee osteoarthritis ( 28916551) Nonsyndromic cleft lip with cleft palate ( 28232668) Nonsyndromic cleft lip with or without cleft palate ( 33898419) Orofacial cleft x maternal periconceptional alcohol use interaction (2df) ( 33937227) Orofacial cleft x maternal periconceptional multivitamin use interaction (2df) ( 33937227) Orofacial cleft x maternal periconceptional smoking interaction (2df) ( 33937227) Orofacial clefts ( 22863734 28054174) Percentage gas trapping ( 26030696) Response to amphetamines ( 22952603) Urate levels in lean individuals ( 25811787)
Interacting Genes		16 interacting genes: ASF1A CCNA2 CDK2 H2BC12 H2BC21 H2BC5 H3-3B HIRIP3 HNRNPD NFU1 OGT PAX7 TRIM55 TRIM63 UBE2I UPF1	12 interacting genes: C1orf109 CIB1 CSNK2A1 CT55 FHL1 HIRA HOMER3 KRTAP19-7 MAGOHB NEDD4 SLC30A7 TCAP
Entrez ID		7290	5081
HPRD ID		02583	01331
Ensembl ID		ENSG00000100084	ENSG00000009709
Uniprot IDs		P54198	P23759
PDB IDs		2I32 5YJE
Enriched GO Terms of Interacting Partners?
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