TTN and EXOSC10

Number of citations of the paper that reports this interaction (PubMedID 23414517)
13

Data Source:
BioGRID (two hybrid)

		TTN	EXOSC10
Description		titin	exosome component 10
Image
GO Annotations	Cellular Component	Condensed Nuclear Chromosome Extracellular Region Cytosol Z Disc I Band Extracellular Exosome	Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Membrane Transcriptionally Active Chromatin
	Molecular Function	Protease Binding Protein Serine/threonine Kinase Activity Protein Tyrosine Kinase Activity Calcium Ion Binding Protein Binding Calmodulin Binding ATP Binding Structural Constituent Of Muscle Enzyme Binding Protein Kinase Binding Telethonin Binding Identical Protein Binding Actinin Binding Protein Self-association Actin Filament Binding Muscle Alpha-actinin Binding Structural Molecule Activity Conferring Elasticity Protein Serine Kinase Activity	Nucleotide Binding 3'-5'-exoribonuclease Activity RNA Binding Single-stranded RNA Binding Exoribonuclease Activity Protein Binding Telomerase RNA Binding
	Biological Process	Cardiac Muscle Hypertrophy Muscle Contraction Striated Muscle Contraction Mitotic Chromosome Condensation Positive Regulation Of Gene Expression Protein Kinase A Signaling Peptidyl-tyrosine Phosphorylation Skeletal Muscle Thin Filament Assembly Skeletal Muscle Myosin Thick Filament Assembly Detection Of Muscle Stretch Sarcomere Organization Regulation Of Protein Kinase Activity Sarcomerogenesis Positive Regulation Of Protein Secretion Regulation Of Catalytic Activity Response To Calcium Ion Cardiac Myofibril Assembly Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Cardiac Muscle Contraction	Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay Maturation Of 5.8S RRNA Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) Nuclear-transcribed MRNA Catabolic Process RRNA Processing Dosage Compensation By Inactivation Of X Chromosome Negative Regulation Of Telomere Maintenance Via Telomerase Nuclear MRNA Surveillance CUT Catabolic Process Nuclear Polyadenylation-dependent RRNA Catabolic Process Nuclear Polyadenylation-dependent SnoRNA Catabolic Process Nuclear Polyadenylation-dependent SnRNA Catabolic Process Nuclear Polyadenylation-dependent TRNA Catabolic Process Nuclear Polyadenylation-dependent CUT Catabolic Process Nuclear Polyadenylation-dependent Antisense Transcript Catabolic Process Histone MRNA Catabolic Process Nuclear Retention Of Unspliced Pre-mRNA At The Site Of Transcription Polyadenylation-dependent SnoRNA 3'-end Processing Regulation Of Telomerase RNA Localization To Cajal Body
Pathways		Platelet degranulation Striated Muscle Contraction	Major pathway of rRNA processing in the nucleolus and cytosol
Drugs
Diseases
GWAS		Atrial fibrillation ( 29290336 30061737 29892015) Bone mineral density (hip) ( 30172743) Breast size ( 22747683) Dilated cardiomyopathy (MTAG) ( 33495596) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits (multivariate) ( 32602732) Epstein-Barr virus copy number in lymphoblastoid cell lines ( 28654678) Heart rate response to recovery post exercise (10 sec) ( 29497042) Heart rate response to recovery post exercise (20 sec) ( 29497042) Hypertrophic cardiomyopathy (sarcomere negative) ( 33495597) Left ventricular ejection fraction ( 33495596 32382064) Left ventricular end-diastolic volume ( 33495596 32382064) Left ventricular end-systolic volume ( 33495596 32382064) Left ventricular global circumferential strain ( 33495596) Left ventricular global radial strain ( 33495596) Left ventricular mass ( 33495596) PR interval ( 30046033 32439900) QT interval ( 20031603 29213071 24952745 29874175) Rapid functional decline in sporadic amyotrophic lateral sclerosis ( 26746183) Refractive error ( 32231278) Resting heart rate ( 27798624) Sick sinus syndrome ( 33580673) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)	Beard thickness ( 26926045) Heel bone mineral density ( 30598549) Intraocular pressure ( 29617998)
Interacting Genes		77 interacting genes: ABLIM1 ABLIM2 ACTA1 ACTN1 ACTN2 ACTN3 ACTN4 AMOT ANK1 ANKRD1 ANKRD2 ANKRD23 ANKRD28 ASH2L ATP5F1D C1QTNF9 CALM1 CAPN3 CCT6A CHD4 CLIP4 CRYAB DNAJB5 DNAJB6 DUSP6 ENO1 ENO3 EXOSC10 FHL1 FHL2 FLNA FN1 FNDC3B GABARAP HSPA1B HSPB2 ITGB1BP2 ITGB5 JPH1 LIMS1 MAPK1 MAST2 MYBPC1 MYBPC2 MYBPC3 MYBPH MYCBP2 MYH9 MYOM1 MYOM2 MYPN NBR1 NEB NEK9 NEO1 OBSCN PARD3 PHGDH POMP PYGM RNF167 RPL12 RYR1 SF1 SGCG SH3GLB1 SQSTM1 SRPK2 TAB2 TCAP TRIM55 TRIM63 TSC22D2 TTC3 UBE2I UGP2 VAV2	37 interacting genes: ALDH1B1 B9D1 CHPF CIB1 DIS3 DXO EIF3M EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC8 FERMT3 FOXRED1 IMMT LCAT LSM2 LSM8 MPHOSPH6 NOMO1 NOMO2 PALS2 PTGES2 RPE RUVBL2 SCRIB SKIV2L SSRP1 SUMO2 TARDBP TOX4 TTN UPF2 USP16 USP21 XRN1 XRN2
Entrez ID		7273	5394
HPRD ID		01787	16180
Ensembl ID		ENSG00000155657	ENSG00000171824
Uniprot IDs		A0A0A0MRA3 A0A0A0MTS7 Q7Z3B7 Q8WZ42	Q01780
PDB IDs		1BPV 1G1C 1NCT 1NCU 1TIT 1TIU 1TKI 1TNM 1TNN 1WAA 1YA5 2A38 2BK8 2F8V 2ILL 2J8H 2J8O 2NZI 2RQ8 2WP3 2WWK 2WWM 2Y9R 3B43 3KNB 3LCY 3LPW 3PUC 3Q5O 3QP3 4C4K 4JNW 4O00 4QEG 4UOW 5BS0 5JDD 5JDE 5JDJ 5JOE 6DL4 6H4L 6HCI 6I0Y 6SDB 7NIP	2CPR 3SAF 3SAG 3SAH 6D6Q 6D6R
Enriched GO Terms of Interacting Partners?
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