C3 and C3AR1

Number of citations of the paper that reports this interaction (PubMedID 11342658)
63

Data Source:
HPRD (in vitro)

		C3	C3AR1
Description		complement C3	complement C3a receptor 1
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Protein-containing Complex Secretory Granule Lumen Azurophil Granule Lumen Extracellular Exosome Blood Microparticle	Plasma Membrane Integral Component Of Plasma Membrane Azurophil Granule Membrane Specific Granule Membrane
	Molecular Function	Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding C5L2 Anaphylatoxin Chemotactic Receptor Binding	Complement Receptor Activity Complement Component C3a Receptor Activity G Protein-coupled Receptor Activity
	Biological Process	Positive Regulation Of Type IIa Hypersensitivity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Activation Of Membrane Attack Complex Fatty Acid Metabolic Process Inflammatory Response Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Response To Bacterium Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Glucose Transmembrane Transport Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Lipid Storage Negative Regulation Of Endopeptidase Activity Neuron Remodeling Oviduct Epithelium Development Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Phagocytosis, Engulfment Amyloid-beta Clearance Complement-dependent Cytotoxicity Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Cell Surface Receptor Signaling Pathway Involved In Cell-cell Signaling Positive Regulation Of Apoptotic Cell Clearance	Complement Receptor Mediated Signaling Pathway Chemotaxis Inflammatory Response G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Circulation Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of Macrophage Chemotaxis Positive Regulation Of Angiogenesis Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G Protein-coupled Signaling Pathway Positive Regulation Of Neutrophil Chemotaxis
Pathways		Alternative complement activation Activation of C3 and C5 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Peptide ligand-binding receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (i) signalling events Neutrophil degranulation Post-translational protein phosphorylation Purinergic signaling in leishmaniasis infection Regulation of Complement cascade	Peptide ligand-binding receptors G alpha (i) signalling events Neutrophil degranulation Purinergic signaling in leishmaniasis infection Regulation of Complement cascade
Drugs		Human immunoglobulin G Zinc S-Hydroxycysteine Mirococept Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385819 20385826 23455636 20861866 21665990) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (geographic atrophy) ( 22705344) Blood protein levels ( 30072576 29875488) Complement C3 and C4 levels ( 23028341) Complement C3 levels ( 33941608) Disease progression in age-related macular degeneration ( 29346644) Early age-related macular degeneration ( 32843070) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lymphocyte counts ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Triglycerides ( 24097068) White blood cell count ( 32888494)	Granulocyte percentage of myeloid white cells ( 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252)
Interacting Genes		38 interacting genes: ABL1 AGR2 ATG16L1 C2 C3AR1 C5 C5AR2 CD46 CFB CFH CFHR3 CFHR4 CFHR5 CFI CFP CPN1 CR1 CR2 CTSG EFEMP2 GC GOLGA6L9 HMGB1 HSP90AA1 ICAM3 ITGAM ITGAX ITGB2 KRT31 KRTAP10-8 LAMA1 LRP1 MASP1 OLFM4 PAPPA PLEKHF2 TGM2 VSIG4	3 interacting genes: C3 C4A SNTA1
Entrez ID		718	719
HPRD ID		00400	05581
Ensembl ID		ENSG00000125730	ENSG00000171860
Uniprot IDs		B4DR57 P01024 V9HWA9	A8K2H7 Q16581
PDB IDs		1C3D 1GHQ 1W2S 2A73 2A74 2GOX 2I07 2ICE 2ICF 2NOJ 2QKI 2WII 2WIN 2WY7 2WY8 2XQW 2XWB 2XWJ 3D5R 3D5S 3G6J 3L3O 3L5N 3NMS 3OED 3OHX 3OXU 3RJ3 3T4A 4HW5 4HWJ 4I6O 4M76 4ONT 4ZH1 5FO7 5FO8 5FO9 5FOA 5FOB 5NBQ 5O32 5O35 6EHG 6RMT 6RMU 6RUR 6RUV 6S0B
Enriched GO Terms of Interacting Partners?
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