TPO and DUOX1

Number of citations of the paper that reports this interaction (PubMedID 15561711)
22

Data Source:
HPRD (in vivo)

		TPO	DUOX1
Description		thyroid peroxidase	dual oxidase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Endoplasmic Reticulum Plasma Membrane Cell Surface Apical Plasma Membrane Cell Leading Edge NADPH Oxidase Complex
	Molecular Function	Iodide Peroxidase Activity Peroxidase Activity Calcium Ion Binding Heme Binding	Peroxidase Activity Calcium Ion Binding Protein Binding NAD(P)H Oxidase H2O2-forming Activity Superoxide-generating NAD(P)H Oxidase Activity Heme Binding NADP Binding NADH Oxidase H202-forming Activity NADPH Oxidase H202-forming Activity
	Biological Process	Thyroid Hormone Generation Response To Oxidative Stress Embryonic Hemopoiesis Hormone Biosynthetic Process Hydrogen Peroxide Catabolic Process Cellular Oxidant Detoxification	Thyroid Hormone Generation Defense Response Response To Oxidative Stress Cytokine-mediated Signaling Pathway Cuticle Development Hormone Biosynthetic Process Superoxide Anion Generation Hydrogen Peroxide Catabolic Process Hydrogen Peroxide Biosynthetic Process Response To CAMP Positive Regulation Of Wound Healing Cellular Oxidant Detoxification Positive Regulation Of Cell Motility
Pathways		Thyroxine biosynthesis	Thyroxine biosynthesis
Drugs		Carbimazole Dextrothyroxine Propylthiouracil Methimazole Triclosan Resorcinol 2-mercaptobenzothiazole
Diseases
GWAS		Autoimmune thyroid disease ( 32581359) Hypothyroidism ( 30367059 27182965) Medication use (thyroid preparations) ( 31015401) Placebo response in major depressive disorder (% change in symptom score) ( 28696415) Thrombin-activatable fibrinolysis inhibitor levels ( 29378355) Thyroid peroxidase antibody levels ( 24586183) Thyroid peroxidase antibody positivity ( 24722205 24586183) Thyroid stimulating hormone levels ( 32769997)
Interacting Genes		3 interacting genes: DUOX1 DUSP6 TXNDC11	2 interacting genes: TPO TXNDC11
Entrez ID		7173	53905
HPRD ID		06000	08421
Ensembl ID		ENSG00000115705	ENSG00000137857
Uniprot IDs		P07202 Q502Y3 Q6P534	Q9NRD9
PDB IDs			7D3E 7D3F
Enriched GO Terms of Interacting Partners?
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