TPH1 and PSTPIP1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
86

Data Source:
BioGRID (two hybrid)

		TPH1	PSTPIP1
Description		tryptophan hydroxylase 1	proline-serine-threonine phosphatase interacting protein 1
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GO Annotations	Cellular Component	Cytosol Neuron Projection	Uropod Cytoplasm Cytosol Actin Filament Plasma Membrane Membrane Lamellipodium Cleavage Furrow Perinuclear Region Of Cytoplasm
	Molecular Function	Tryptophan 5-monooxygenase Activity Iron Ion Binding Protein Binding	Protein Binding Identical Protein Binding Actin Filament Binding
	Biological Process	Platelet Degranulation Aromatic Amino Acid Family Metabolic Process Serotonin Biosynthetic Process Regulation Of Hemostasis	Endocytosis Inflammatory Response Cell Adhesion Signal Transduction Actin Filament Polymerization Innate Immune Response
Pathways		Serotonin and melatonin biosynthesis NGF-stimulated transcription	The NLRP3 inflammasome Purinergic signaling in leishmaniasis infection
Drugs		Sapropterin LX1031 Telotristat ethyl
Diseases
GWAS		Glucose homeostasis traits ( 30576415) HDL cholesterol ( 30275531) White blood cell count ( 32888494)	Hip circumference adjusted for BMI ( 34021172) Neurofibrillary tangles ( 31497858) Neutrophil count ( 32888494) White blood cell count ( 32888494)
Interacting Genes		6 interacting genes: APP GORASP2 PRKACA PSTPIP1 YWHAH YWHAZ	65 interacting genes: ABL1 AXIN1 BUB3 CCDC172 CD2 CD2AP CHD4 CWF19L2 DHX40 DNM2 EHHADH EXOC5 FAM90A1 FASLG FBXL18 HAPLN2 HHEX HMG20A HSF2BP IL16 KANK2 KHDRBS1 LIN37 LSM4 MCRS1 MEFV MFGE8 MOS MVP NAV2 NCBP1 PCDHB14 PNKP PRPF31 PRR35 PTPN12 PTPN18 RINT1 RNPS1 RPL9 RTP5 RXRB SCNM1 SDCBP SH2D4A SHBG SMARCD1 SPG7 SYCE1 TFIP11 TPH1 TRAF3IP3 TSGA10IP TTC1 TULP3 UBE2W WAS WASF1 WASF2 WASL ZC2HC1C ZNF175 ZNF408 ZNF580 ZNF688
Entrez ID		7166	9051
HPRD ID		01846	05891
Ensembl ID		ENSG00000129167	ENSG00000140368
Uniprot IDs		P17752	A0A0S2Z5P3 O43586
PDB IDs		1IN9 1MLW 3HF6 3HF8 3HFB 5J6D 5L01 5TPG	2DIL
Enriched GO Terms of Interacting Partners?
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