TNFRSF1B and HIVEP3

Number of citations of the paper that reports this interaction (PubMedID 11804591)
22

Data Source:
HPRD (in vivo)

		TNFRSF1B	HIVEP3
Description		TNF receptor superfamily member 1B	HIVEP zinc finger 3
Image			No pdb structure
GO Annotations	Cellular Component	Tumor Necrosis Factor Receptor Superfamily Complex Extracellular Region Nucleus Plasma Membrane Membrane Integral Component Of Membrane Specific Granule Membrane Neuronal Cell Body Varicosity Membrane Raft Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm
	Molecular Function	Tumor Necrosis Factor-activated Receptor Activity Protein Binding Ubiquitin Protein Ligase Binding Tumor Necrosis Factor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Metal Ion Binding
	Biological Process	Regulation Of Cytokine Production Involved In Immune Response Regulation Of T Cell Cytokine Production Aortic Valve Development Pulmonary Valve Development Negative Regulation Of Extracellular Matrix Constituent Secretion Inflammatory Response Immune Response Aging Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Negative Regulation Of Cardiac Muscle Hypertrophy Regulation Of Myelination Positive Regulation Of Myelination Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of T Cell Proliferation Positive Regulation Of Oligodendrocyte Differentiation RNA Destabilization Positive Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of Cell Death Cellular Response To Lipopolysaccharide Cellular Response To Growth Factor Stimulus Extrinsic Apoptotic Signaling Pathway Regulation Of Neuroinflammatory Response Negative Regulation Of Neuroinflammatory Response Glial Cell-neuron Signaling Negative Regulation Of Neuron Death Positive Regulation Of Apoptotic Process Involved In Morphogenesis Regulation Of RNA Biosynthetic Process	Regulation Of Transcription By RNA Polymerase II Skeletal Muscle Cell Differentiation Positive Regulation Of Transcription, DNA-templated
Pathways		TNFR2 non-canonical NF-kB pathway TNFs bind their physiological receptors Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation	Regulation of RUNX2 expression and activity
Drugs		Tasonermin
Diseases
GWAS		Asthma ( 31959851) Blood protein levels ( 30072576 29875488) Blood protein levels in cardiovascular risk ( 28369058) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Tuberculosis ( 29036319) Urate levels (BMI interaction) ( 25811787)	Adult body size ( 32376654) Airway imaging phenotypes ( 26030696) Breast cancer ( 29059683) Bronchopulmonary dysplasia ( 23897914) Diastolic blood pressure ( 27618452) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Eye color ( 33692100) General risk tolerance (MTAG) ( 30643258) Gut microbiota (functional units) ( 27694959) Heel bone mineral density ( 30598549) High myopia ( 32428537) Intraocular pressure ( 29235454) Left ventricular obstructive tract defect (maternal effect) ( 28468790) Lupus nephritis in systemic lupus erythematosus ( 24925725) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Night sleep phenotypes ( 27126917) Pulse pressure ( 27841878 30578418) Refractive error ( 32231278) Spatial memory ( 31596458) Spherical equivalent or myopia (age of diagnosis) ( 29808027) Squamous cell lung carcinoma ( 28604730) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 27841878 27618452 30578418) Treatment resistant depression ( 30468137) White blood cell count ( 32888494)
Interacting Genes		22 interacting genes: ADAM17 BMX CAV1 CD14 CSNK1A1 CSNK1A1L FANCD2 HIVEP3 ICAM3 KRT18 LTA PKN1 STAT1 TDP2 TNF TRAF1 TRAF2 TRAF3 TRAIP TRIM37 UBQLN1 ZNF420	5 interacting genes: FHL1 RUNX2 TNFRSF1B TRAF1 TRAF2
Entrez ID		7133	59269
HPRD ID		01862	09442
Ensembl ID		ENSG00000028137	ENSG00000127124
Uniprot IDs		P20333	Q5T1R4
PDB IDs		1CA9 3ALQ
Enriched GO Terms of Interacting Partners?
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