TNFAIP1 and SVIL

Number of citations of the paper that reports this interaction (PubMedID 20309963)
28

Data Source:
BioGRID (two hybrid)

		TNFAIP1	SVIL
Description		TNF alpha induced protein 1	supervillin
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Endosome Cytosol Cul3-RING Ubiquitin Ligase Complex	Podosome Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Actin Cytoskeleton Midbody Cleavage Furrow Microtubule Minus-end Cell Projection Costamere
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Cyclin Binding Small GTPase Binding Identical Protein Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Actin Filament Binding
	Biological Process	Apoptotic Process Immune Response Cell Migration Protein Ubiquitination Negative Regulation Of Rho Protein Signal Transduction Stress Fiber Assembly Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of DNA Replication Protein Homooligomerization	Skeletal Muscle Tissue Development Actin Polymerization Or Depolymerization Positive Regulation Of Cytokinesis Actin Filament Severing Barbed-end Actin Filament Capping
Pathways		RND3 GTPase cycle RND2 GTPase cycle
Drugs
Diseases
GWAS		Blood protein levels ( 29875488) Low density lipoprotein cholesterol levels ( 29403010) Osteoprotegerin levels ( 25080503)	Age-related cognitive decline (language) (slope of z-scores) ( 30954325) Bone fracture in osteoporosis ( 28580392) Dilated cardiomyopathy ( 33495596) Dilated cardiomyopathy (MTAG) ( 33495596) Estimated glomerular filtration rate ( 31152163) Lung function (FEV1/FVC) ( 28166213) Metabolite levels ( 23823483) Neurofibrillary tangles ( 25188341) Normalized brain volume ( 19010793) Platelet thrombus formation ( 22550155) Plateletcrit ( 32888494)
Interacting Genes		34 interacting genes: ARMC7 ARNT CAPN7 CARD9 CDC37 CSNK2B DAPP1 EPHA2 EPM2AIP1 EXOSC5 FXR1 FXR2 HAT1 HEXIM2 KCTD10 KCTD13 KDM1A LNX1 NTAQ1 NXF1 POLR1C PRKAG1 PSMA1 RHOA RHOB RIN3 SMARCA2 SMARCB1 STK16 SUV39H1 SVIL TRIM54 ZDHHC17 ZMYND19	36 interacting genes: AR ATRX BUB1 CENPF DYNLT1 ESR1 FLNA HAX1 HMMR HSP90AA1 ITGB3BP KIF22 KIFC3 KMT2A KRT18 LMNA LMNB2 LUC7L2 MIF4GD MPHOSPH9 MRTFB NME2 NR3C1 ODF2 P2RX7 PAN3 PCNX3 PPARG SH3PXD2A SLAMF7 STARD9 TGFB1I1 TNFAIP1 TRIP6 UXT YWHAG
Entrez ID		7126	6840
HPRD ID		01856	04992
Ensembl ID		ENSG00000109079	ENSG00000197321
Uniprot IDs		Q13829	A0A6I8PIX7 O95425 Q569J5
PDB IDs			2K6M 2K6N
Enriched GO Terms of Interacting Partners?
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