TLR4 and HMGB1

Number of citations of the paper that reports this interaction (PubMedID 16267105)
310

Data Source:
HPRD (in vivo)

		TLR4	HMGB1
Description		toll like receptor 4	high mobility group box 1
Image
GO Annotations	Cellular Component	Ruffle Phagocytic Cup Cytoplasm Early Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Cell Surface Endosome Membrane Intrinsic Component Of Plasma Membrane Receptor Complex Lipopolysaccharide Receptor Complex Perinuclear Region Of Cytoplasm	Condensed Chromosome Extracellular Region Extracellular Space Nucleus Nucleoplasm Early Endosome Endoplasmic Reticulum-Golgi Intermediate Compartment Cell Surface Transcription Repressor Complex Secretory Granule Lumen Alphav-beta3 Integrin-HMGB1 Complex Neuron Projection Ficolin-1-rich Granule Lumen
	Molecular Function	Lipopolysaccharide Binding Amyloid-beta Binding Lipopolysaccharide Immune Receptor Activity Transmembrane Signaling Receptor Activity Signaling Receptor Binding Protein Binding Signaling Receptor Activity Identical Protein Binding Protein Heterodimerization Activity NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating	Four-way Junction DNA Binding Bubble DNA Binding Transcription Cis-regulatory Region Binding Lipopolysaccharide Binding Phosphatidylserine Binding Damaged DNA Binding Double-stranded DNA Binding Single-stranded DNA Binding Transcription Coactivator Activity RNA Binding Double-stranded RNA Binding Single-stranded RNA Binding Cytokine Activity Integrin Binding Protein Binding Transcription Factor Binding DNA Binding, Bending Calcium-dependent Protein Kinase Regulator Activity Lyase Activity C-X-C Chemokine Binding Protein Kinase Activator Activity Chemoattractant Activity RAGE Receptor Binding DNA Polymerase Binding Supercoiled DNA Binding DNA-binding Transcription Factor Binding
	Biological Process	Activation Of Innate Immune Response Toll-like Receptor Signaling Pathway Wound Healing Involved In Inflammatory Response B Cell Proliferation Involved In Immune Response Nitric Oxide Production Involved In Inflammatory Response Regulation Of Dendritic Cell Cytokine Production MyD88-dependent Toll-like Receptor Signaling Pathway Phagocytosis Inflammatory Response Immune Response I-kappaB Phosphorylation Positive Regulation Of Platelet Activation Positive Regulation Of Gene Expression Astrocyte Development Positive Regulation Of Smooth Muscle Cell Migration Detection Of Fungus Positive Regulation Of B Cell Proliferation Lipopolysaccharide-mediated Signaling Pathway Response To Lipopolysaccharide Detection Of Lipopolysaccharide Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-17 Production Negative Regulation Of Interleukin-23 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Chemokine Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production Toll-like Receptor 4 Signaling Pathway TRIF-dependent Toll-like Receptor Signaling Pathway Cellular Response To Platelet-derived Growth Factor Stimulus T-helper 1 Type Immune Response Macrophage Activation Defense Response To Bacterium Positive Regulation Of Macrophage Activation Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAP Kinase Activity Innate Immune Response Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of Osteoclast Differentiation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Inflammatory Response Defense Response To Gram-negative Bacterium Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Intestinal Epithelial Structure Maintenance Positive Regulation Of Macrophage Cytokine Production Negative Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Positive Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Mechanical Stimulus Cellular Response To Interferon-gamma Negative Regulation Of Cold-induced Thermogenesis Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Positive Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Oxidative Stress-induced Neuron Death Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Positive Regulation Of Cellular Response To Macrophage Colony-stimulating Factor Stimulus Positive Regulation Of Matrix Metallopeptidase Secretion Cellular Response To Amyloid-beta Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production	Negative Regulation Of Transcription By RNA Polymerase II Eye Development Myeloid Dendritic Cell Activation Endothelial Cell Proliferation Activation Of Innate Immune Response Plasmacytoid Dendritic Cell Activation Macrophage Activation Involved In Immune Response Dendritic Cell Chemotaxis Inflammatory Response To Antigenic Stimulus Regulation Of Tolerance Induction Regulation Of T Cell Mediated Immune Response To Tumor Cell DNA Topological Change Base-excision Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Regulation Of Transcription By RNA Polymerase II Autophagy Inflammatory Response Signal Transduction Positive Regulation Of Cytosolic Calcium Ion Concentration Positive Regulation Of Autophagy Gene Silencing Negative Regulation Of RNA Polymerase II Transcription Preinitiation Complex Assembly Lung Development Neuron Projection Development Chromatin Assembly Regulation Of Restriction Endodeoxyribonuclease Activity Activation Of Protein Kinase Activity DNA Geometric Change Positive Regulation Of Mismatch Repair Negative Regulation Of Interferon-gamma Production Positive Regulation Of Interferon-alpha Production Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-1 Beta Production Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Tumor Necrosis Factor Production V(D)J Recombination Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Positive Regulation Of Toll-like Receptor 4 Signaling Pathway Positive Regulation Of Toll-like Receptor 9 Signaling Pathway T-helper 1 Cell Activation Endothelial Cell Chemotaxis Positive Regulation Of Activated T Cell Proliferation Positive Regulation Of Apoptotic Process Apoptotic Cell Clearance Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Negative Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of DNA Binding Positive Regulation Of MAPK Cascade Positive Regulation Of Blood Vessel Endothelial Cell Migration Negative Regulation Of Blood Vessel Endothelial Cell Migration T-helper 1 Cell Differentiation Innate Immune Response Positive Regulation Of Myeloid Cell Differentiation Positive Regulation Of Glycogen Catabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Positive Chemotaxis Positive Regulation Of DNA Ligation Response To Glucocorticoid Positive Regulation Of ERK1 And ERK2 Cascade Cellular Response To Lipopolysaccharide Positive Regulation Of Monocyte Chemotactic Protein-1 Production Positive Regulation Of Monocyte Chemotaxis Positive Regulation Of Wound Healing Neutrophil Clearance Cellular Response To Interleukin-7 Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Sprouting Angiogenesis Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Negative Regulation Of Apoptotic Cell Clearance Regulation Of Nucleotide-excision Repair Positive Regulation Of Dendritic Cell Differentiation
Pathways		ER-Phagosome pathway Caspase activation via Death Receptors in the presence of ligand Toll Like Receptor 4 (TLR4) Cascade MyD88:MAL(TIRAP) cascade initiated on plasma membrane MyD88-independent TLR4 cascade TRIF-mediated programmed cell death MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon IKK complex recruitment mediated by RIP1 TRAF6-mediated induction of TAK1 complex within TLR4 complex Heme signaling IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation	ER-Phagosome pathway Apoptosis induced DNA fragmentation MyD88:MAL(TIRAP) cascade initiated on plasma membrane TAK1 activates NFkB by phosphorylation and activation of IKKs complex MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Pyroptosis Regulation of TLR by endogenous ligand Neutrophil degranulation Advanced glycosylation endproduct receptor signaling Advanced glycosylation endproduct receptor signaling TRAF6 mediated NF-kB activation
Drugs		Cyclobenzaprine Naloxone (R)-3-hydroxytetradecanoic acid Lauric acid Eritoran Golotimod E5531 Myristic acid Papain Mifamurtide	Chloroquine Ethyl pyruvate
Diseases
GWAS		Adult body size ( 32376654) Blood protein levels ( 29875488 28240269) BMI (adjusted for smoking behaviour) ( 28443625) BMI in non-smokers ( 28443625) Body mass index ( 25673413 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index (joint analysis main effects and smoking interaction) ( 28443625) Body mass index in physically active individuals ( 28448500) Body size at age 10 ( 32376654) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Cognitive decline rate in late mild cognitive impairment ( 26252872) Daytime nap ( 33568662) Experiencing mood swings ( 29500382) Feeling fed-up ( 29500382) Feeling guilty ( 29500382) Impulsivity (motor) ( 30718321) Irritable mood ( 29500382) LDL cholesterol levels in HIV infection ( 33109212) Metabolite levels ( 23823483) Neurociticism ( 29500382) Neuroticism ( 29255261) Obesity-related traits ( 23251661) Osteoarthritis biomarkers ( 25057126) Plasma omega-6 polyunsaturated fatty acid levels (dihomo-gamma-linolenic acid) ( 24823311) Prostate-specific antigen levels ( 28139693) Triglyceride levels in HIV infection ( 33109212) Voxel-wise structural brain imaging measurements in Alzheimerâ€™s disease ( 30584014)	Adult body size ( 32376654) Apolipoprotein A1 levels ( 32203549) Blood osmolality (transformed sodium) ( 28360221) Carotid plaque burden ( 28282560) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Hippocampal volume ( 21116278) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Rapid response to perioperative phenylephrine (change in mean arterial pressure) ( 33168928) Red blood cell count ( 32888494) Triglyceride levels ( 32203549 32154731) Type 2 diabetes ( 30297969) Urate levels ( 31578528)
Interacting Genes		26 interacting genes: BCL10 BTK CD14 CNPY4 DEFB4A HMGB1 HSP90B1 IRAK1 IRAK2 LY96 MAPK8IP3 MYD88 NOX4 RAB14 RIPK2 RNF216 SERTAD1 SIGIRR SMAD3 SYK TICAM2 TIRAP TLR1 TLR5 TOLLIP UBQLN1	123 interacting genes: ACBD3 AGER AGTRAP ALK AR ATOH1 C1QBP C3 CASP3 CCAR1 CCNDBP1 CDK1 CEBPB CREBBP CRMP1 CSNK1A1 CTCF CTNNBL1 CUX1 DLAT DNAAF2 DNM2 DNMT1 DUX4 EIF1 ENAH EP300 ERF ERG28 FIP1L1 FLT1 FOS FOXA3 FOXC1 GOLM1 GTF2A1 HDLBP HES1 HMGA1 HNRNPK HNRNPU HOXA10 HOXB1 HOXB3 HOXC6 HOXD10 HOXD11 HOXD3 HOXD8 HOXD9 HPF1 HR HSPA5 IRF2 KRT7 LRIF1 MAP1B MAPKAPK5 MECP2 MIEN1 MNAT1 MNT MT2A NCAN NEUROD6 NEXN NFKB1 NR3C1 PCOLCE PGR PLAT PLG POU5F1 PPP2R3A PRKCA PRKDC PSEN1 PSMA7 PTPN2 PTPRZ1 RAD23B RAG1 RASAL2 RASSF4 RB1 RBPJ RELA RFX1 RPL29 RPS12 RPS20 RSF1 SIX5 SOX18 SPIN1 SPINT1 SRSF3 TAF1 TAF3 TBP TERF2 TERF2IP TFE3 TGIF1 TGM3 TLE1 TLE2 TLE5 TLR2 TLR4 TP53 TP73 UBC UBE2E3 UBE2I UBXN1 UHRF2 UNC119 WNK4 YY1 ZFP36 ZNF24 ZNF428
Entrez ID		7099	3146
HPRD ID		04325	01228
Ensembl ID		ENSG00000136869	ENSG00000189403
Uniprot IDs		O00206	A0A024RDR0 P09429
PDB IDs		2Z62 2Z63 2Z65 2Z66 3FXI 3UL7 3UL8 3UL9 3ULA 4G8A 5NAM 5NAO	2LY4 2RTU 2YRQ 6CG0 6CIJ 6CIK 6CIL 6CIM 6OEM 6OEN 6OEO
Enriched GO Terms of Interacting Partners?
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